Umwandlung von Krötengiften (Bufadienoliden) durch Mikroorganismen. II. 12β‐Hydroxyresibufogenin. 12. Mitteilung über Reaktionen mit Mikroorganismen

Abstract

Volumen 47, Fasciculus 8 (1964) -No. 247-248 2. I ergab mit o-Phenylendiamin bei Siedetemperatur VIII in 94% Ausbeute. 3. Die Umsetzung von I mit 1,8-Diaminonaphtalin in kochendem Nitrobenzol 2217 ergab eine Subatanz, die wahrscheinlich das Naphtimidazol V darstellt.

Isolation and Structure of Five New Cancer Cell Growth Inhibitory Bufadienolides from the Chinese Traditional Drug Ch'an Su

“…Instead bufadienolides 6, 7, and 8 had been obtained by semisynthesis from, respectively, bufotalin (17), resibufagin, 6 and resibufogenin (11). 7 The structural elucidation of bufadienolides 6, 7, and 8 was accomplished employing the analogous spectral interpretation procedures used for assigning structures 1-5.…”

“…Among the previously known bufadienolides ( 6 − 20 ) we isolated from Ch'an Su during this investigation, three ( 6 , 7 , and 8 ) had not been discovered earlier as natural products. Instead bufadienolides 6 , 7 , and 8 had been obtained by semisynthesis from, respectively, bufotalin ( 17 ), resibufagin, and resibufogenin ( 11 ) . The structural elucidation of bufadienolides 6 , 7 , and 8 was accomplished employing the analogous spectral interpretation procedures used for assigning structures 1 − 5 .…”

“…Cancer Cell Growth Inhibitory Activity of the New Bufadienolides (1-5) and Related Bufadienolides(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) …”