Umweltinduzierte frühe Prägung von Asthma und Epigenetik

Krauss‐Etschmann, Susanne; Aneja, Manish Kumar; N, Schulz

doi:10.1007/s00112-009-2084-9

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…Grundsätzlich sind genetische sowie vermutlich auch epigenetische Faktoren für die Entwicklung eines Asthma bronchiale im Kindesalter relevant (s. auch [14,17]) und könnten bereits früh in der Immunentwicklung eine wichtige Rolle spielen.…”

Section: Allergieentstehung Oder -Protektionunclassified

Asthma bronchiale

Schaub

2010

Monatsschr Kinderheilkd

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LeitthemaEpidemiologische, klinische und immunologische Studien [2, 9, 23, 24, 25] deuten darauf hin, dass die Entstehung des Asthma bronchiale bereits pränatal sowie im 1. Lebensjahr durch eine Veränderung der Immunregulation geprägt werden kann. Auf deren Entwicklung wirken verschiedene als Risiko-bzw. Schutzfaktoren des Asthma bronchiale angesehene Einflüsse ein. In einem komplexen Netzwerk genetischer und epigenetischer Faktoren und Umwelteinflüs-sen trägt die Immunregulation dazu bei, ob ein Kind im Verlauf der Immunentwicklung ein Asthma entwickelt oder möglicherweise davor geschützt ist.

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Section: Allergieentstehung Oder -Protektionunclassified

Asthma bronchiale

Schaub

2010

Monatsschr Kinderheilkd

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Comparison of influenza A virus infection in high‐ and low‐birth‐weight pigs using morphometric analysis

Detmer

Gunvaldsen

Harding

2013

Influenza Resp Viruses

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BackgroundEpigenetic studies have shown that low‐birth‐weight (LBW) and growth restriction has been associated with reduced immune function in humans and reduced passive immunity in pigs. To examine the immune responses of high‐birth‐weight (HBW) and LBW groups of pigs, influenza A virus infection was used as an exemplifier of neonatal respiratory disease.ObjectivesThe objectives of this study were (i) to compare clinical, immunological, and pathological outcome of influenza infection in HBW to LBW pigs and (ii) to establish standardized sampling sites, score each site independently with set criteria, and compare scores between sites.MethodsSixty‐eight 4‐week‐old pigs originating from either HBW or LBW litters were intratracheally inoculated with 106·3 TCID 50/ml of A/swine/Texas/4199‐2/1998 H3N2 and euthanized 48 hours later. Samples were collected 2·5 cm from the tip of both cranial and middle lung lobes. The formalin‐fixed paraffin‐embedded tissue sections were scored in a blinded manner by a single pathologist using established scoring criteria for routine and immunohistochemical stains. Clinical parameters, lung and nasal swab virus titers, and cytokine levels for interferon‐alpha and interleukin‐1‐beta, IL‐6, and IL‐8 were measured.Results and ConclusionsLung lesion severity and influenza staining intensity were significantly lower in LBW compared with HBW pigs (P < 0·05). Additionally, examining just the LBW group, the significant difference between lobes (P = 0·009) showed that the mean score for the right cranial lung lobe was higher compared with the other three lobes.

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Umweltinduzierte frühe Prägung von Asthma und Epigenetik

Cited by 2 publications

References 32 publications

Asthma bronchiale

Asthma bronchiale

Comparison of influenza A virus infection in high‐ and low‐birth‐weight pigs using morphometric analysis

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