Un falso positivo para β2-transferrina en rinorrea. Traumatismo ocular

García-Callejo, Francisco Javier er; Expósito, F. Martínez; Martí, Beatriz Pallarés; Fernández, Andrea Rubio; Oishi, Natsuki; García, J.R. Alba

doi:10.1016/j.oftal.2019.05.016

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…Since B2‐Tf is also found in aqueous humor (and potentially vitreous humor), severe orbital injuries like globe rupture may result in FP results on B2‐Tf GE 10,11,37 . Orbital fluids with B2‐Tf may drain into sinonasal cavities and cause a FP result 11 . Another rare potential FP could occur from an orbital cyst communicating with the sinonasal cavities 37 .…”

Section: Discussionmentioning

confidence: 99%

“…10,11,37 Orbital fluids with B2-Tf may drain into sinonasal cavities and cause a FP result. 11 Another rare potential FP could occur from an orbital cyst communicating with the sinonasal cavities. 37 Kelly et al also reported salivary contamination of otorrhea causing an actual FP on B2-Tf GE, which was ultimately confirmed by assessing salivary amylase levels in the otorrhea.…”

Section: Orbital and Oral Contaminationmentioning

confidence: 99%

“…8,9 B2-Tf can be detected in CSF, aqueous and vitreous humor, and variably in perilymph, but not in in normal nasal or otologic secretions or serum. [10][11][12][13] B2-Tf is derived from transferrin, a glycoprotein formed predominantly in hepatocytes, but also in the central nervous system (choroid plexus), as well as in the orbit, testes, and mammary glands. Transferrin's main role is to bind and carry iron to various tissues.…”

Section: Introductionmentioning

confidence: 99%

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Systematic review of errors on beta‐2 transferrin gel electrophoresis testing of rhinorrhea and otorrhea

Eide,

Mason,

Ray

et al. 2023

Int Forum Allergy Rhinol

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BackgroundBeta‐2 transferrin (B2‐Tf) gel electrophoresis (GE) is the preferred non‐invasive diagnostic modality for confirming cerebrospinal fluid (CSF) in body fluids. While B2‐Tf GE testing is highly sensitive and specific for CSF, false‐positive (FP) and false‐negative (FN) results can lead to diagnostic and therapeutic dilemmas. Several series have demonstrated potential causes of false B2‐Tf GE results, but few studies have reported reasons for these errors. The purpose of this systematic review was to describe sources of B2‐Tf GE errors.MethodsA systematic review was performed by searching OVID, EMBASE, and Web of Science databases for B2‐Tf GE studies. After applying exclusion criteria, original research studies directly addressing erroneous B2‐Tf GE results underwent qualitative analysis.ResultsOf the 243 abstracts screened, 71 underwent full‐text review and 18 studies reporting B2‐Tf GE errors were included for analysis. There were 15 potential FPs, 12 actual FPs, 12 potential FNs, 19 actual FNs, and 14 indeterminate results. There were also 246 potentially indeterminate results from in vitro studies. Reasons for B2‐Tf GE errors included serum transferrin alterations (n = 17; all potential), infection related (n = 13; 9 potential), orbital or salivary contamination (n = 2; 1 potential), and collection related (n = 255; 246 potential). There were 31 false or indeterminate results with unspecified reasons. There were no reported errors due to laboratory processing.ConclusionsMultiple potential or actual reasons for false or indeterminate results have been reported for B2‐Tf GE testing of rhinorrhea and otorrhea. Future studies should explore reasons for B2‐Tf testing errors and how these may affect clinical decision making.

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Section: Discussionmentioning

confidence: 99%