Un nouveau cas de syndrome de Rowell

Schissler, C.; Banea, S.; Tortel, M.-C.; Mahé, A.

doi:10.1016/j.annder.2017.02.005

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…A similar case report of a 43-year-old woman who developed RS during treatment with esomeprazole has been mentioned. 6 The woman was on treatment with esomeprazole. Subsequently, the woman developed skin eruption and was initially diagnosed with lupus erythematosus.…”

Section: Discussionmentioning

confidence: 99%

“…She was eventually diagnosed with RS (time to reaction onset not stated) and was treated with corticosteroids and hydroxychloroquine and a positive outcome was achieved. 6 Amatya et al 12 described a case of RS secondary to anti-tubercular therapy. There were erythematous targetoid lesions and non-blanchable purpura on her back and extremities including palms and soles.…”

Section: Discussionmentioning

confidence: 99%

“…4 Proton pump inhibitors were described in the literature for drug-induced RS. [5][6][7] We describe a rare overlap syndrome of SLE and EM-like skin lesions.…”

Section: Introductionmentioning

confidence: 99%

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Drug Induced Rowell’s Syndrome: A Rare Presentation

Rana,

Thapa,

Shrestha

et al. 2024

Nep. Med. Coll. J.

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Rowell’s syndrome (RS) is a rare disorder characterized by Erythema multiforme (EM)-like lesions in a patient with lupus erythematosus, either systemic lupus erythematosus (SLE) or cutaneous lupus erythematosus (CLE). A 35 years old female presented in our dermatology outpatient department (OPD) with complaint of hemorrhagic crusting of lips and multiple discrete targetoid lesions over the chest, upper limb, and gluteal region. Investigations revealed a speckled pattern of antinuclear antibody (ANA), anti-Smith antibody, anti-ds DNA antibody, and strongly positive anti-Ro antibody. According to the clinical evaluation and investigations, the diagnosis of drug induced RS was made. The likely role of proton pump inhibitors, namely esomeprazole as a triggering factor is discussed. After stopping esomeprazole and starting medications with oral steroids and hydroxychloroquine, her good response to treatment was noted.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Drug Induced Rowell’s Syndrome: A Rare Presentation

Rana,

Thapa,

Shrestha

et al. 2024

Nep. Med. Coll. J.

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“…Rowell syndrome is rare, as more cases will be reported the existence of this entity will be further clarified. Despite the refined diagnostic criteria, recent literature has debated on whether RS is an overlap syndrome, a real association, or coincidence of DLE and EM [9] . This case reflects that we should suspect Rowell syndrome even in young patients without precipitating features and further cases must be reported to help increase knowledge of pathophysiology of Rowell syndrome.…”

Section: Discussionmentioning

confidence: 99%

Rowell syndrome in pregnancy: A diagnostic challenge

Jaryal,

Mahajan

2023

Int. J. Clin. Obstet. Gynaecol.

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Rowell syndrome is comprised of erythema multiforme-like lesions in association with lupus erythematosus along with serologies of speckled antinuclear antibodies, positive rheumatoid factor, positive anti-La/ anti-Ro and the clinical finding of chilblains. 1 Rowell syndrome is currently classified as a subtype of chronic cutaneous lupus erythematosus. 2 The majority of cases are seen in women aged 20-70 years. The ratio of affected women to men is 8:1. Indian patients have a median age of 23 compared to age 32 worldwide and are less likely to be discoid lupus. 3 We report a case of Rowell syndrome in pregnancy. A 29 year old primigravida at the period of gestation 15 weeks developed vasculitic lesions, erythema multiforme-like lesions in palms, soles, oral ulceration suggestive of LE lesions. She also had Alopecia universalis, Taenia corporaris and scabies masking the lesions of Rowell syndrome which was a diagnostic challenge. Laboratory investigations revealed ANA+1:640 speckled, Anti Ro+++, Anti La +++. The histology of the targetoid lesions was consistent with erythema multiforme. The patient was successfully managed on low-dose aspirin and hydroxychloroquine. Lesions showed significant improvement in one month. Early diagnosis, multidisciplinary team approach, and intensive monitoring during the antenatal period were key to the successful outcome of patient who had normal vaginal delivery of female child at term. This case reflects that we should suspect Rowell syndrome even in young patients without precipitating features and further cases must be reported to help increase knowledge of the pathophysiology of Rowell syndrome.

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“…For Torchia et al There are no significant histological differences between Cutaneous Lupus Erythematosus (CLE) and EM lesions and the presence of necrotic keratinocytes is not specific to EM as it can also be found in CLE lesions [9]. Although diagnostic criteria have been established in the literature, the reality of this entity is still disputed [10]. The annular and targetoid appearance of the skin lesions can be confused with subacute lupus erythematosus and erythema multiforme.…”

Section: Discussionmentioning

confidence: 99%