Un-united fractures of the distal radius: A report of 12 cases

Segalman, Keith A.; Clark, Gaylord L.

doi:10.1016/s0363-5023(98)80173-1

Cited by 79 publications

(67 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Type I diabetes mellitus negatively alters the mechanical and biologic properties of bone [3,22] and has been associated with an increased risk of complications with fracture healing, including delayed union, wound necrosis, and increased incidence of infection [6,8,23,25,28]. An intervention that would overcome this inhibition of fracture healing would be useful clinically.…”

Section: Discussionmentioning

confidence: 99%

“…Type I diabetes mellitus is associated with an increased risk of complications with fractures, including delayed union, wound necrosis, and increased incidence of infection [6,8,23,25,28]. Many of these complications result from progressive small vessel arterial disease and peripheral neuropathy that develop with time and are largely untreatable [19,29].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Osteogenic Protein-1 Overcomes Inhibition of Fracture Healing in the Diabetic Rat: A Pilot Study

Kidder

Chen

Schmidt

et al. 2008

Clin Orthop Relat Res

View full text Add to dashboard Cite

Type I diabetes mellitus inhibits fracture healing and leads to an increase in complications. As a pilot study, we used a closed fracture model in the diabetic rat to address the question of whether osteogenic protein-1 (OP-1) in a collagen carrier can overcome this inhibition by increasing the area of the newly mineralized callus and femoral torque to failure compared with diabetic animals with fractures treated without OP-1. Diabetes was created in 54 rats by injection of streptozotocin. After 2 weeks, a closed femur fracture was created using a drop-weight impaction device. Each fracture site was immediately opened and treated with or without 25 lg OP-1 in a collagen carrier. Animals were euthanized after 2 or 4 weeks. Fracture healing was assessed by callus area from highresolution radiographs, callus strength from torsional failure testing, and undecalcified histologic analysis. The area of newly mineralized callus was greater in diabetic animals treated with 25 lg OP-1/carrier compared with diabetic animals with untreated fractures and with fractures treated with carrier alone. This increase in callus area did not translate into an equivalent increase in torque to failure. Osteogenic protein-1 showed some evidence of overcoming the inhibition of fracture healing in the diabetic rat.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Osteogenic Protein-1 Overcomes Inhibition of Fracture Healing in the Diabetic Rat: A Pilot Study

Kidder

Chen

Schmidt

et al. 2008

Clin Orthop Relat Res

View full text Add to dashboard Cite

show abstract

“…26 Some investigators believe that the increased use of surgical techniques that create a gap in the metaphysis of the distal radius after restoring its length have resulted in an increased incidence of this complication. 27,28 Inadequate stabilization of the fracture, overdistraction, and other medical factors including diabetes, alcoholism and smoking likely to play a role in the development of delayed union. 25,29 None of the aforementioned factors involved in the development of delayed union, suggest that either external fixation or volar plating would provide an advantage in avoiding this complication.…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of the Complication Profile following Palmar Plating versus External Fixation of Fractures of the Distal Radius

Wartinbee¹,

Miller²,

Riboh³

2011

The Duke Orthopaedic Journal

View full text Add to dashboard Cite

show abstract

“…The causes of non-union or absence of bone consolidation are related to several factors among which stand out: smoking, limbs microangiopathy, metabolic disturbances, hypovitaminosis, prolonged and inadequate immobilization, neoplasic or metastatic disease, hyperparathyroidism, excessive stretch of the fracture with external fixation, open fracture, infection and interposition of soft tissues in the fracture 12,13 .…”

Section: Discussionmentioning

confidence: 99%

Characterization of pseudarthrosis with ultrasound backscattered signals in rats

Ferreira¹,

Matusin²,

Machado³

et al. 2010

Acta Cir. Bras.

View full text Add to dashboard Cite

Purpose:To propose a novel model of pseudarthrosis in a small animal and to investigate the ability of backscatter parameters from ultrasound signals in differentiating normal bone from those ones with pseudarthorsis. Methods: Twelve Rattus norvegicus albinus free from pathogenic species (SPF) were randomly divided in two groups, with six animals each. In the Control group a surgical approach to the femur was made, followed by the synthesis of the muscle and skin layers. The Experimental group was submitted to an osteotomy of the femur and a vascularized flap of the fascia lata was interposed in the line of the fractured bone. Then the alignment and bone stabilization were accomplished, by using nylon stitch in U shape introduced in holes made in the proximal and distal fractured bone. Bone samples were scanned with ultrasound and signals were collected for each one to analyze the parameter Apparent Integrated Backscatter -AIB. Results: Radiological and anatomopathologic studies revealed the absence of bone consolidation with persistence of fiber-osteoid tissue. Values of the ultrasound parameter AIB from normal bones were statistically different from those with pseudarthrosis. Conclusion: The experimental model was suitable for pseudarthrosis development in rats and the ultrasound backscatter parameters were able to identify such a bone disease in vitro. Key words: Disease Models. Animal. Orthopedics. Ultrasonography. Rats. RESUMOObjetivo: Propor um novo modelo de pseudoartrose em animais de pequeno porte e investigar o potencial de parâmetros de retroespalhamento de ultrassônico em diferenciar osso normal e com pseudoartrose. Métodos: Doze Rattus norvegicus albinus (SPF) foram distribuídos aleatoriamente em dois grupos, tendo cada grupo seis animais. No grupo Controle realizou-se uma abordagem cirúrgica ao fêmur, seguida da síntese por planos do músculo e da pele. O grupo Experimental foi submetido à osteotomia do fêmur aduzida da confecção de um retalho pediculado de fascia lata para interposição entre os segmentos resultantes da fratura induzida cirurgicamente. Prosseguiu-se com o alinhamento e estabilização óssea, mediante a confecção de um nó com fio de náilon em formato de U, introduzido em orifícios efetuados nas extremidades proximal e distal à fratura. As amostras ósseas foram irradiadas pelo ultrassom e sinais foram coletados para cada uma no intuito de analisar o parâmetro Retroespalhamento Integrado Aparente -AIB. Resultados: Estudos radiológicos e anatomopatológicos evidenciaram a ausência de consolidação óssea com persistência de tecido fibro-osteóide. Os valores de AIB para ossos normais foram estatisticamente diferentes em relação aos ossos com pseudoartrose. Conclusão: O modelo experimental apresentou-se adequado para a formação de pseudoartrose em ratos e o parâmetro de retroespalhamento de ultrassom foi capaz de detectar tal doença óssea, in vitro. Descritores: Modelos Animais de Doenças. Ortopedia. Ultrassonografia. Ratos

show abstract

Un-united fractures of the distal radius: A report of 12 cases

Cited by 79 publications

References 12 publications

Osteogenic Protein-1 Overcomes Inhibition of Fracture Healing in the Diabetic Rat: A Pilot Study

Osteogenic Protein-1 Overcomes Inhibition of Fracture Healing in the Diabetic Rat: A Pilot Study

Comparative Analysis of the Complication Profile following Palmar Plating versus External Fixation of Fractures of the Distal Radius

Characterization of pseudarthrosis with ultrasound backscattered signals in rats

Contact Info

Product

Resources

About