Unacylated ghrelin is associated with changes in insulin sensitivity and lipid profile during an exercise intervention

Cederberg, Henna; Koivisto, V. A.; Jokelainen, Jari; Surcel, Heljä‐Marja; Keinänen‐Kiukaanniemi, Sirkka; Rajala, Ulla

doi:10.1111/j.1365-2265.2011.04135.x

Cited by 26 publications

(26 citation statements)

References 37 publications

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“…Of the 100 included studies, 46 included young male participants only with 18 (18% of total studies and 39.1% of young adult male only studies) [52–54, 57, 58, 60, 61, 64–73, 76] for physical inactivity, 14 (14% of total studies and 30.4% of young adult male only studies) for unsafe sexual behaviour [51, 80, 82, 85–91, 94, 96–98], 4 (4% of total studies and 8.7% of young adult male only studies) for alcohol use [126–129], 2 (2% of total studies and 4.3% of young adult male only studies) for unsafe vehicle driving [104, 105] 1 (1% of total studies and 2.2% of young adult male only studies) for tobacco smoking [110], 1 (1% of total studies and 2.2% of young adult male only studies) for poor diet [103], and 1 (1% of total studies and 2.2% of young adult male only studies) for tanning/sun exposure [115]. Also 5 (5% of total studies and 10.9% of young adult male only studies) of the studies with only young adult male participants targeted multiple risk behaviours [116, 119, 122, 124, 125].…”

Section: Resultsmentioning

confidence: 99%

“…The remaining interventions were carried out in Europe (n = 18, 18%) [52, 53, 55, 56, 60, 61, 70, 81, 95, 98, 102, 104, 110, 116, 119, 127, 128, 148], Australasia (n = 8, 8%) [54, 65, 66, 105, 108, 120, 124, 149], Asia (n = 6, 6%) [64, 67, 71, 72, 107, 114], South America (n = 3, 3%) [69, 79, 83], Africa (n = 1, 1%) [76] and one intervention (1%) was implemented in multiple countries across two continents (USA, Ecuador, Peru and Brazil) [84]. The risk behaviours that were targeted in various intervention countries, separated by studies with young adult male participants only and studies with outcomes stratified by age/sex to include young adult males are shown in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 100 included studies there were 62 (62%) randomized controlled trials [51–57, 59, 62–73, 75, 77, 78, 82, 84–86, 90, 92, 93, 96, 103, 105, 108, 109, 112, 113, 116, 118–120, 123–125, 127–131, 133–135, 138–140, 143–149], 16 (16%) case series [57, 60, 61, 74, 76, 80, 91, 94, 99–101, 110, 115, 117, 121, 136], 9 (9%) non-randomized controlled trials [87, 95, 98, 102, 104, 107, 122, 137, 141], 7 (7%) cluster randomized controlled trials [79, 81, 83, 111, 126, 132, 142], 4 (4%) cluster controlled studies [45, 88, 97, 114] and 2 (2%) interrupted time series [89, 106]. The number of papers for each study design and reported risk behaviour is provided in Table 3.…”

Section: Resultsmentioning

confidence: 99%

“…Other prevalent settings included military/army (n = 11, 11%) [52, 60, 61, 69, 71, 72, 104, 110, 119, 127, 128] and internet (n = 8, 8%) [45, 85, 92, 113, 132, 139, 148, 149]. Five studies (5%) were delivered in multiple settings [83, 111, 120, 122, 145].…”

Section: Resultsmentioning

confidence: 99%

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A scoping review of risk behaviour interventions in young men

et al. 2014

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BackgroundYoung adult males commonly engage in risky behaviours placing them at risk of acute and chronic health conditions. The purpose of this scoping review was to provide an overview of existing literature, describing the interventions targeting risk behaviours in young adult males.MethodsA search of seven electronic databases, grey literature and relevant journals reported in English language until May 2013 was conducted. All interventions that promoted healthy behaviours or reductions in risky behaviours to treat or prevent an associated health issue(s) in young adult males (17-35 years) in upper-middle and high-income countries were included. For inclusion the appropriate age range had to be reported and the sample had to be young adult male participants only or the outcomes reported with stratification by age and/or sex to include young adult males. Risk behaviours included: physical inactivity, poor diet, alcohol use, tobacco smoking, recreational drug use, unsafe sexual behaviours, tanning/sun exposure, violence, unsafe vehicle driving, gambling and self-harm.ResultsThe search strategy identified 16,739 unique citations and the full-text of 1149 studies were retrieved and screened with 100 included studies focussed on: physical inactivity (27%), alcohol use (25%), unsafe sexual behaviour (21%), poor diet (5%), unsafe vehicle driving (5%), tobacco smoking (4%), recreational drug use (2%), and tanning/sun exposure (1%) with no relevant studies targeting violence, gambling or self-harm. Also 10% of the studies targeted multiple risk behaviours. The most common study design was randomized controlled trials (62%). Face-to-face was the most common form of intervention delivery (71%) and the majority were conducted in university/college settings (46%). There were 46 studies (46%) that included young adult male participants only, the remaining studies reported outcomes stratified by age and/or sex.ConclusionRisk behaviours in young men have been targeted to some extent, but the amount of research varies across risk behaviours. There is a need for more targeted and tailored interventions that seek to promote healthy behaviours or decrease risky behaviours in young men.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2458-14-957) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A scoping review of risk behaviour interventions in young men

et al. 2014

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“…Interestingly, GO-CoA-Tat did not suppress weight gain in ghrelin-deficient mice that lack both AG and DAG, suggesting that these animals are less responsive because of their DAG deficiency (24). Reports suggesting that high DAG levels might be linked to positive metabolic effects include a report by Cederberg et al (25). They found that 6 months of intensive exercise in 552 young men increased DAG levels, which was associated with decreased body weight and improved body composition.…”

Section: European Journal Of Endocrinologymentioning

confidence: 87%

Does des-acyl ghrelin improve glycemic control in obese diabetic subjects by decreasing acylated ghrelin levels?

Özcan¹,

Neggers²,

Miller³

et al. 2014

European Journal of Endocrinology

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Objective: The objective of this study was to assess the effects of a continuous overnight infusion of des-acyl ghrelin (DAG) on acylated ghrelin (AG) levels and glucose and insulin responses to a standard breakfast meal (SBM) in eight overweight patients with type 2 diabetes. Furthermore, in the same patients and two additional subjects, the effects of DAG infusion on AG concentrations and insulin sensitivity during a hyperinsulinemic-euglycemic clamp (HEC) were assessed. Research design and methods: A double-blind, placebo-controlled cross-over study design was implemented, using overnight continuous infusions of 3 and 10 mg DAG/kg per h and placebo to study the effects on a SBM. During a HEC, we studied the insulin sensitivity. Results: We observed that, compared with placebo, overnight DAG administration significantly decreased postprandial glucose levels, both during continuous glucose monitoring and at peak serum glucose levels. The degree of improvement in glycemia was correlated with baseline plasma AG concentrations. Concurrently, DAG infusion significantly decreased fasting and postprandial AG levels. During the HEC, 2.5 h of DAG infusion markedly decreased AG levels, and the M-index, a measure of insulin sensitivity, was significantly improved in the six subjects in whom we were able to attain steady-state euglycemia. DAG administration was not accompanied by many side effects when compared with placebo. Conclusions: DAG administration improves glycemic control in obese subjects with type 2 diabetes through the suppression of AG levels. DAG is a good candidate for the development of compounds in the treatment of metabolic disorders or other conditions with a disturbed AG:DAG ratio, such as type 2 diabetes mellitus or Prader-Willi syndrome.

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Ghrelin Responses to Acute Exercise and Training

Jürimäe

2013

Endocrinology of Physical Activity and Sport

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Unacylated ghrelin is associated with changes in insulin sensitivity and lipid profile during an exercise intervention

Abstract: Increase in UAG level was associated with improved insulin sensitivity via mechanisms independent of weight loss during an intensive, long-term exercise intervention in young healthy men.

Cited by 26 publications

References 37 publications

A scoping review of risk behaviour interventions in young men

A scoping review of risk behaviour interventions in young men

Does des-acyl ghrelin improve glycemic control in obese diabetic subjects by decreasing acylated ghrelin levels?

Ghrelin Responses to Acute Exercise and Training

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