UNC-6/Netrin and its Receptors UNC-5 and UNC-40/DCC Control Growth Cone Polarity, Microtubule Accumulation, and Protrusion

Abstract

13Many axon guidance ligands and their receptors have been identified, but it is still unclear 14 how these ligand-receptor interactions regulate events in the growth cone, such as protrusion 15 and cytoskeletal arrangement, during directed outgrowth in vivo. In this work, we dissect the 16 multiple and complex effects of UNC-6/Netrin on the growth cone. Previous studies showed 17 that in C. elegans, the UNC-6/Netrin receptor UNC-5 regulates growth cone polarity, as 18 evidenced by loss of asymmetric dorsal F-actin localization and protrusion in unc-5 mutants. (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.