UNC5B‐AS1 promoted ovarian cancer progression by regulating the H3K27me on NDRG2 via EZH2

Wang, Hao; Su, Hong; Tan, Yujie

doi:10.1002/cbin.11300

Cited by 23 publications

(18 citation statements)

References 29 publications

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“…As one of the research hot spots in recent years, growing lncRNAs have been discovered, and their role in OC progression has been announced by increasing researches with the development of next-generation sequencing technology. For example, UNC5B-AS1 is upregulated in OC tissues, and overexpressing UNC5B-AS1 enhances proliferation and inhibits apoptosis of OC tissues ( 18 ). In addition, lncRNA TUBA4B is downregulated in epithelial OC tissues and is compactly related to the FIGO stage and distant metastasis of OC patients ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

A Positive Feedback Loop of lncRNA DSCR8/miR-98-5p/STAT3/HIF-1α Plays a Role in the Progression of Ovarian Cancer

et al. 2020

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Background Accumulating studies have revealed that long non-coding RNA (lncRNA) and microRNA (miRNA) contribute to ovarian cancer (OC). DSCR8 has been found to mediate hepatocellular carcinoma development, while its role in OC remains to be explored. Methods In this study, lncRNA DSCR8 and miR-98-5p expressions in OC tissues and adjacent non-cancer tissues were determined by reverse transcriptase polymerase chain reaction (RT-PCR). Besides, gain-of-function or loss-of-function assays of DSCR8 and miR-98-5p were conducted on OC cell lines SKOV-3 and A2780. Cell proliferation was detected with Cell Counting Kit (CCK)8 and colony formation assay, and western blot was used to test the apoptotic levels of OC cells. Transwell assay was conducted to examine cell invasion, and the epithelial–mesenchymal transition (EMT) of OC cells was tested by western blot. Moreover, luciferase activity assay and RNA immunoprecipitation (RIP) assay were conducted to verify the relationships between DSCR8 and miR-98-5p, miR-98-5p, and signal transducer and activator of transcription 3 (STAT3). Results DSCR8 was remarkedly increased in OC tissues and associated with poorer survival of OC patients. Overexpressing DSCR8 promoted cell proliferation, invasion, and EMT but inhibited apoptosis. On the other hand, miR-98-5p was downregulated in OC tissues and relieved the progression of OC. Moreover, overexpressed DSCR8 increased the levels of STAT3 and hypoxia inducible factor 1 alpha (HIF-1α) and dampened the functions of miR-98-5p on OC. Pharmaceutical intervention of STAT3 and HIF-1α significantly altered the expressions of DSCR8 and miR-98-5p. Conclusion The present results suggested a positive feedback loop of lncRNA DSCR8/miR-98-5p/STAT3/HIF-α axis in the progression of OC.

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Section: Discussionmentioning

confidence: 99%

A Positive Feedback Loop of lncRNA DSCR8/miR-98-5p/STAT3/HIF-1α Plays a Role in the Progression of Ovarian Cancer

et al. 2020

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“…Until now, there are only several literatures correlated with UNC5B-AS1 in cancers can be searched. These studies reveal that UNC5B-AS1 is upregulated and relevant to proliferation, migration and invasion in ovarian cancer, breast cancer, thyroid cancer and colon cancer [28][29][30][31]. However, there have no reports of UNC5B-AS1 in GBM.…”

Section: Discussionmentioning

confidence: 99%

A long non-coding RNA signature predicts survival for glioblastoma as prognostic biomarkers

Z¹,

Z²,

Lu³

et al. 2020

Preprint

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Background: Glioblastoma (GBM) is one of the most fatal tumors in the central nervous system. Its prognosis is very poor. There is increasing evidence that long noncoding RNA (lncRNA) participates in the biological process of glioblastoma. Nevertheless, the role of lncRNA in predicting the prognosis of GBM is still uncertain. Methods: In this study, using RNA-Seq and clinical follow-up data of GBM patients from The Cancer Genome Atlas (TCGA), we performed differential analysis of lncRNA, univariable and multivariable Cox regression analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and Gene Ontology (GO) analysis.Results: We identified four lncRNAs closely interrelated with survival and prognosis of GBM patients. This lncRNA signature was effective in both the training set and the testing set, and it was independent to clinical factors.Conclusions: Our data suggested that the four lncRNAs could be used as promising biomarkers for predicting prognosis in GBM patients.

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“…This kind of regulation can be also in cis, although no examples have yet been described for OC. However, several examples have been described in OC for lncRNA-based PRC2 guidance, specifically of EZH2, an active subunit of PRC, to the loci of target genes: LINC00511 and TP73-AS1 guide EZH2 to the p21 locus [72,95]; LINC00702 guides it to the KLF2 locus [39]; LINC01210 to the KLF4 locus [27]; ABHD11-AS1 to the TIMP2 locus [136]; and UNC5B-AS1 to the NDRG2 locus [137].…”

Section: Transcriptional Regulationmentioning

confidence: 99%

The Challenges and Opportunities of LncRNAs in Ovarian Cancer Research and Clinical Use

Salamini-Montemurri

Lamas-Maceiras

Barreiro-Alonso

et al. 2020

Cancers

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Ovarian cancer is one of the most lethal gynecological malignancies worldwide because it tends to be detected late, when the disease has already spread, and prognosis is poor. In this review we aim to highlight the importance of long non-coding RNAs (lncRNAs) in diagnosis, prognosis and treatment choice, to make progress towards increasingly personalized medicine in this malignancy. We review the effects of lncRNAs associated with ovarian cancer in the context of cancer hallmarks. We also discuss the molecular mechanisms by which lncRNAs become involved in cellular physiology; the onset, development and progression of ovarian cancer; and lncRNAs' regulatory mechanisms at the transcriptional, post-transcriptional and post-translational stages of gene expression. Finally, we compile a series of online resources useful for the study of lncRNAs, especially in the context of ovarian cancer. Future work required in the field is also discussed along with some concluding remarks.

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UNC5B‐AS1 promoted ovarian cancer progression by regulating the H3K27me on NDRG2 via EZH2

Cited by 23 publications

References 29 publications

A Positive Feedback Loop of lncRNA DSCR8/miR-98-5p/STAT3/HIF-1α Plays a Role in the Progression of Ovarian Cancer

A Positive Feedback Loop of lncRNA DSCR8/miR-98-5p/STAT3/HIF-1α Plays a Role in the Progression of Ovarian Cancer

A long non-coding RNA signature predicts survival for glioblastoma as prognostic biomarkers

The Challenges and Opportunities of LncRNAs in Ovarian Cancer Research and Clinical Use

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