Uncarboxylated Matrix G1a Protein as a Predictor of Lung Function

Abstract

Matrix G1a protein (MGP) is expressed in elastin rich tissue and is a potent inhibitor of calcification and subsequently of elastin degradation. MGP is activated by vitamin K-dependent mechanisms from uncarboxylated MGP (ucMGP) to carboxylated MGP. Prior studies have demonstrated lower vitamin K levels are associated with higher elastin degradation in COPD and idiopathic pulmonary fibrosis, suggesting that the MGP pathway may be important in maintaining lung function. Whether circulating levels of ucMGP are associated with lung function and chronic lung disease remains unclear.