Uncaria tomentosa improves cognition, memory and learning in middle-aged rats

Castilhos, Lívia Gelain; Oliveira, Juliana Sorraila de; Adefegha, Stephen A.; Manzoni, Alessandra Guedes; Passos, Daniela F.; Assmann, Charles Elias; Silveira, Leonardo Lanes da; Trelles, Kelly Bordin; Kronbauer, Maikel; Doleski, Pedro H.; Bremm, João M.; Braun, Josiane Bizzi Schlemmer; Abdalla, Fátima Husein; Gonçalves, Jamile Fabbrin; Andrade, Cínthia Melazzo de; Cruz, Ivana Beatrice Mânica da; Bürger, Marilise Escobar

doi:10.1016/j.exger.2020.111016

Cited by 8 publications

(3 citation statements)

References 45 publications

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“…Uncaria tomentosa (Uña de Gato or Cat’s claw) is a vine of the Rubiaceae family with antimutagenic and neuroprotective properties. The polyphenols, sterols, and alkaloids present in Cat’s Claw have shown a positive effect in cholinergic dysfunction, inhibiting AChE activity and DNA repairment, avoiding oxidative stress and inflammation, and thus, cardiovascular and autoimmune diseases [ 49 , 50 , 51 ]. Physalis peruviana (Aguaymanto) is a berry of the Solanaceae family with anti-inflammatory and cytoprotective properties in astrocytic cells (T98G) exposed to neurotoxic stimuli, preserving mitochondrial functions and nuclei damage [ 52 , 53 ].…”

Section: Resultsmentioning

confidence: 99%

In Silico Analysis of Metabolites from Peruvian Native Plants as Potential Therapeutics against Alzheimer’s Disease

et al. 2022

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Background: Despite research on the molecular bases of Alzheimer’s disease (AD), effective therapies against its progression are still needed. Recent studies have shown direct links between AD progression and neurovascular dysfunction, highlighting it as a potential target for new therapeutics development. In this work, we screened and evaluated the inhibitory effect of natural compounds from native Peruvian plants against tau protein, amyloid beta, and angiotensin II type 1 receptor (AT1R) pathologic AD markers. Methods: We applied in silico analysis, such as virtual screening, molecular docking, molecular dynamics simulation (MD), and MM/GBSA estimation, to identify metabolites from Peruvian plants with inhibitory properties, and compared them to nicotinamide, telmisartan, and grapeseed extract drugs in clinical trials. Results: Our results demonstrated the increased bioactivity of three plants’ metabolites against tau protein, amyloid beta, and AT1R. The MD simulations indicated the stability of the AT1R:floribundic acid, amyloid beta:rutin, and tau:brassicasterol systems. A polypharmaceutical potential was observed for rutin due to its high affinity to AT1R, amyloid beta, and tau. The metabolite floribundic acid showed bioactivity against the AT1R and tau, and the metabolite brassicasterol showed bioactivity against the amyloid beta and tau. Conclusions: This study has identified molecules from native Peruvian plants that have the potential to bind three pathologic markers of AD.

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Section: Resultsmentioning

confidence: 99%

In Silico Analysis of Metabolites from Peruvian Native Plants as Potential Therapeutics against Alzheimer’s Disease

et al. 2022

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“…The current work is the first attempt at determining whether oral consumption of CAE may improve attention. Literature reviews and research studies have suggested that CAE can be used to prevent or limit neurocognitive deficits (Batiha et al., 2020; Castilhos et al., 2020; Quinn et al., 2004; Shi et al., 2013; Snow et al., 2019). However, the studies suffer from multiplicity and inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

Oral intake of carboxy alkyl ester improves attention: A randomized double‐blind cross‐over placebo‐controlled study

Guthrie,

Yang

2023

Human Psychopharmacology

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ObjectiveTo test the null hypothesis that oral intake of the dietary supplement carboxy alkyl ester (CAE) would have no effect on attention as revealed by mean rapid visual information processing (RVIP) scores.MethodsIn a randomized double‐blind cross‐over placebo‐controlled trial, healthy participants (age 19–66 years) of both sexes were randomly assigned to consume 700 mg of CAE or 700 mg of placebo. They received baseline attention testing via the RVIP task. Then they consumed CAE or placebo followed by RVIP testing. Participants were then given a washout period where they did not consume CAE or placebo. Afterward, individuals who initially consumed CAE were given the placebo and those who initially consumed the placebo were given CAE. Finally, all participants were tested again via RVIP.ResultsA priori statistical computation revealed that 30‐day oral intake of CAE improved mean RVIP test scores (t = 2.4, p < .05) relative to that at baseline, which resulted in a rejection of the null hypothesis.ConclusionsDaily oral intake of the CAE dietary supplement may boost attention and further research is now needed to confirm this observation.

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“…U. tomentosa has been known to possess extensive pharmacological activities, including anti-oxidative, anti-inflammatory, immune modulatory and anti-tumor activities [27]. Recent studies showed that U. tomentosa could alleviate the cognitive and memory impairments in both APP transgenic mice and middle-aged rats [28,29]. However, the potency of the anti-AD effect of U. rhynchophylla and U. tomentosa has not been compared so far.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the chemical constituents and anti-Alzheimer’s disease effects of Uncaria rhynchophylla and Uncaria tomentosa

Shaw

et al. 2021

Chin Med

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Background Uncaria tomentosa, which has similar chemical constituents with Uncaria rhynchophylla, has been reported to alleviate cognitive impairments in Alzheimer’s disease (AD) animal models. This study aimed to compare the chemical constituents and anti-AD effect of the ethanol extracts of U. tomentosa (UTE) and U. rhynchophylla (URE). Methods The high-performance liquid chromatography (HPLC) was used to compare the chemical constituents of UTE and URE. Streptozotocin (STZ) was intracerebroventricularly (ICV) injected into adult male Sprague–Dawley (SD) rats to establish AD model. UTE (400 mg/kg) or URE (400 mg/kg) was administrated intragastrically once daily to the rats for 6 consecutive weeks. Morris water maze (MWM) test was conducted to assess the neurological functions in the STZ-induced AD rats. The brain tissues of the rats were harvested for further biochemical assay. Results The MWM test results showed both UTE and URE could significantly improve the learning and memory impairments induced by STZ in rats. Both UTE and URE could significantly inhibit the hyperphosphorylation of tau protein, reduce the elevated levels of pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α), enhance activities of antioxidant enzymes (SOD, CAT and GPx) and increase the protein expression of HO-1. In addition, UTE could decrease the malondialdehyde (MDA) level. Furthermore, both UTE and URE significantly enhanced Akt activation, down regulated the activation of glycogen synthase kinase 3β (GSK-3β), and induced the nuclear translocation of Nrf2 in the STZ-induced AD rats. Conclusions UTE and URE contained similar chemical constituents. We found for the first time that both of them could ameliorate cognitive deficits in the STZ-induced AD rats. The underlying molecular mechanism involve suppression of tau hyperphosphorylation, anti-oxidant and anti-neuroinflammation via modulating Akt (Ser473)/GSK3β (Ser9)-mediated Nrf2 activation. These findings amply implicate that both of UTE and URE are worthy of being developed clinically into pharmaceutical treatment for AD.

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Uncaria tomentosa improves cognition, memory and learning in middle-aged rats

Cited by 8 publications

References 45 publications

In Silico Analysis of Metabolites from Peruvian Native Plants as Potential Therapeutics against Alzheimer’s Disease

In Silico Analysis of Metabolites from Peruvian Native Plants as Potential Therapeutics against Alzheimer’s Disease

Oral intake of carboxy alkyl ester improves attention: A randomized double‐blind cross‐over placebo‐controlled study

Comparison of the chemical constituents and anti-Alzheimer’s disease effects of Uncaria rhynchophylla and Uncaria tomentosa

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