Uncatalyzed synthesis, thermal and mechanical properties of polyurethanes based on poly(ε-caprolactone) and 1,4-butane diisocyanate with uniform hard segment

Heijkants, R. G. J. C.; Calck, R.V. van; Tienen, T.G. van; Groot, J.H. de; Buma, P.; Pennings, A. J.; Veth, Reen P.H.; Schouten, A.J.

doi:10.1016/j.biomaterials.2004.11.005

Cited by 133 publications

(119 citation statements)

References 34 publications

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“…It should be noted that crystallinity is also dependent on the types of HS applied [35,36]. Decrease of phase mixing or increase of phase mixing may, thus, result in crystallinity increase due do domain dominance as may be observed in the results of Heijkants et al [37]. As it would be expected, glass transition temperature increases with increasing HS/SS ratio [33,38].…”

Section: Compositionmentioning

confidence: 74%

A Novel Approach for the Utilization of Biocellulose Nanofibres in Polyurethane Nanocomposites for Potential Applications in Bone Tissue Implants

Khan

Dahman

2012

Designed Monomers and Polymers

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With the increasing number of surgical bone grafts per year, the application of biomaterials in tissue engineering has become a popular issue. In the present work, the potential of biocellulose-nanofibre-reinforced polyurethane nanocomposites to act as bone scaffold implants is established. Investigating properties of polyurethane shows that this widely applied biomaterial group cannot fulfil all properties required for bone implants in a stand-alone fashion. Bone implants require a high Young's modulus and tensile strength but low strain which makes it difficult to find a suitable polyurethane since higher hard segment content will reduce tensile strength and lower hard segment content will reduce the Young's modulus. Other factors such as biodegradation also become important. A literature review on carbon nanotube and nanofibre composites with polyurethanes shows that nanofibrous reinforcement leads to favourable implant properties. Young's modulus and tensile strength increase dramatically. Other properties such as thermal conductivity and viscosity are also affected. These types of nanofibrous materials, however, are the subject of an ongoing debate about toxicity and their use in bone implants is questionable. Biocellulose nanofibres formed from bacteria (also called bacterial cellulose (BC)) possess favourable mechanical properties and are highly biocompatible. A survey on works done on BC nanofibres and their composites show that nanostructured biocomposites that contains the nanofibres reinforced in polymer composites result in changes that are comparable to those of carbon nanotubes in regards to bone scaffold applications. Showing improvement on biocompatibility and mechanical properties, biocellulose nanofibre reinforcement on polyurethanes possesses strong potential for bone implants and other tissue-engineering applications.

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Section: Compositionmentioning

confidence: 74%

A Novel Approach for the Utilization of Biocellulose Nanofibres in Polyurethane Nanocomposites for Potential Applications in Bone Tissue Implants

Khan

Dahman

2012

Designed Monomers and Polymers

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“…In this respect, the range of mechanical and morphological properties that can be obtained with PUR is significantly larger than with commonly used medical grade biodegradable polymers for example: PLA, PGA, poly(DL-lactide) (PDLLA) [39][40][41][42]. Many applications of segmented PUR in TE field, such as cardiovascular TE [34,43,44] musculoskeletal applications (anterior cruciate ligament) [42], knee joint meniscus [45], bone TE [46], smooth muscle cell constructs for contractile muscle [47,48], and nerve regeneration [49][50][51], have been recently evaluated. For polyurethanes containing aromatic isocyanate moieties like methane-4,4'-diphenyldiisocyanate (MDI) and 2,4-toluenediisocyanate (TDI) toxic aromatic diamines were indicated after degradation.…”

Section: Polyurethanes In Tementioning

confidence: 99%

Ascorbic Acid in Polyurethane Systems for Tissue Engineering

Kucińska-Lipka¹,

St.²,

Janik³

et al. 2016

ChChT

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Abstract. The introduction of the paper was devoted to the main items of Tissue Engineering (TE) and the way of porous structure obtaining as scaffolds. Furthermore, the significant role of the scaffold design in TE was described. It was shown, that properly designed polyurethanes (PURs) find application in TE due to the proper physicochemical, mechanical and biological properties. Then the use of L-ascorbic acid (L-AA) in PUR systems for TE was described. L-AA has been applied in this area due to its suitable biological characteristics and antioxidative properties. Moreover, L-AA influences tissue regeneration due to improving collagen synthesis, which is a primary component of the extracellular matrix (ECM). Modification of PUR with L-AA leads to the materials with higher biocompatibility and such system is promising for TE applications.

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“…In this study, they compared the outcome of total meniscectomy with that of the implant of a PU-PCL total meniscal implant. This work followed a large series of in vitro and in vivo experimental studies on the development of this scaffold (Heijkants et al, 2005;Heijkants et al, 2004;van Tienen et al, 2009). The authors described satisfactory integration and fibrovascular tissue ingrowth into the implant with mild foreign body reaction.…”

Section: Total Meniscus Engineeringmentioning

confidence: 99%

Meniscus repair and regeneration: review on current methods and research potential

Scotti

Hirschmann

Antinolfi

et al. 2013

eCM

130

123

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Meniscus regeneration is an unsolved clinical challenge. Despite the wide acceptance of the degenerative consequences of meniscectomy, no surgical procedure has succeeded to date in regenerating a functional and long-lasting meniscal fibrocartilage. Research proposed a number of experimental approaches encompassing all the typical strategies of regenerative medicine: cellfree scaffolds, gene therapy, intra-articular delivery of progenitor cells, biological glues for enhanced bonding of reparable tears, partial and total tissue engineered meniscus replacement. None of these approaches has been completely successful and can be considered suitable for all patients, as meniscal tears require specific and patientrelated treatments depending on the size and type of lesion. Recent advances in cell biology, biomaterial science and bioengineering (e.g., bioreactors) have now the potential to drive meniscus regeneration into a series of clinically relevant strategies. In this tutorial paper, the clinical need for meniscus regeneration strategies will be explained, and past and current experimental studies on meniscus regeneration will be reported.

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Uncatalyzed synthesis, thermal and mechanical properties of polyurethanes based on poly(ε-caprolactone) and 1,4-butane diisocyanate with uniform hard segment

Cited by 133 publications

References 34 publications

A Novel Approach for the Utilization of Biocellulose Nanofibres in Polyurethane Nanocomposites for Potential Applications in Bone Tissue Implants

A Novel Approach for the Utilization of Biocellulose Nanofibres in Polyurethane Nanocomposites for Potential Applications in Bone Tissue Implants

Ascorbic Acid in Polyurethane Systems for Tissue Engineering

Meniscus repair and regeneration: review on current methods and research potential

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