“…First, as negative consequences, uncertainty may cause a great deal of psychosocial stress and enhance personal and family hardship (Lazarus & Folkman, 1984;Mishel, 1981;Strauss et al, 1984). Increased uncertainty has been associated with increased stress (Davis, 1990;Lee, 2006;Mishel, 1981;Wonghongkul, Dechaprom, Phumivichuvate, & Losawatkul, 2006), more psychological mood disturbance (Christman et al, 1988;McCain & Cella, 1995;Mishel & Braden, 1987;Mishel, Hostetter, King, & Graham, 1984), increased anxiety (McCormick et al, 2006;Santacroce, 2002), lower level of quality of life (Carroll, Hamilton, & McGovern, 1999), reduced coping effectiveness (Bennett, 1993), and perception of diminished or lower health status (Carroll et al, 1999). Therefore, uncertainty in illness has been identified as one of the single greatest sources of psychosocial stress to patients (Kroocher, 1985).…”