Uncertainty in heterogeneity estimates in meta-analyses

Ioannidis, John P. A.; Patsopoulos, Nikolaos A.; Εvangelou, Εvangelos

doi:10.1136/bmj.39343.408449.80

Cited by 1,052 publications

(766 citation statements)

References 23 publications

(6 reference statements)

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“…Finally, to detect publication biases, we measured the degree of asymmetry by using Egger's unweighted regression asymmetry test [25]. All analyses were performed using the Meta-Analysis Program [26].…”

Section: Methodsmentioning

confidence: 99%

An association of adverse psychosocial factors with diabetes mellitus: a meta-analytic review of longitudinal cohort studies

2008

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Aims/hypothesis There has been substantial interest in the association between psychosocial stress and risk of diabetes mellitus, but no data on the systematic quantification of the causal relationship have been published. This analysis aims to evaluate the association between adverse psychosocial factors and diabetes mellitus. Methods We performed a search of Medline, PsycINFO, Web of Science and PubMed up to July 2008. The studies included were prospective cohort studies investigating the association between adverse psychosocial factors and risk of diabetes mellitus. Results There were 22 relationships between psychosocial factors and disease-related factors (in 14 papers), of which 16 evaluated the associations of adverse psychosocial factors with diabetes control in diabetic populations and six evaluated the associations of adverse psychosocial factors with the incidence of diabetes in populations without any diagnosed diabetes. The overall meta-analysis demonstrated that adverse psychosocial factors were significantly associated with poor diabetes control (combined correlation coefficient, r=0.096, p=0.006), whereas adverse psychosocial factors were not associated with incident diabetes mellitus. More notably, sensitivity analyses showed that low social support was more robustly associated with poor diabetes control than stressful events per se or stress-prone personality or coping style, and that adverse psychosocial factors were associated with poor control of type 1 and type 2 diabetes. Conclusions/interpretation The current review revealed a detrimental association of psychosocial factors with the prognosis of both type 1 and type 2 diabetes. However, any aetiological effect of adverse psychosocial factors remains elusive as a result of the small number of individuals enrolled in the cohorts studied.

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Section: Methodsmentioning

confidence: 99%

An association of adverse psychosocial factors with diabetes mellitus: a meta-analytic review of longitudinal cohort studies

2008

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“…It should be noted, however, that I-squared fell well within the acceptable limits, i.e., ≤ 60% [50] in the majority of meta-analyses. In addition, a 95% confidence interval for the I-squared was not available for those studies where heterogeneity was high: this prevents us from concluding that heterogeneity was in effect falling outside acceptable limits [51].…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Conduct problems trajectories and psychosocial outcomes: a systematic review and meta-analysis

Bevilacqua

Hale

Barker

et al. 2017

Eur Child Adolesc Psychiatry

143

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“…Statistical heterogeneity was evaluated using the I 2 statistic [9,10]; the 95% CI for I 2 were calculated using Higgins et al's method [12,13]. Where I 2 was >50%, the degree of heterogeneity was considered high.…”

Section: Outcome Measuresmentioning

confidence: 99%

Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis

et al. 2017

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Uncertainty in heterogeneity estimates in meta-analyses

Cited by 1,052 publications

References 23 publications

An association of adverse psychosocial factors with diabetes mellitus: a meta-analytic review of longitudinal cohort studies

An association of adverse psychosocial factors with diabetes mellitus: a meta-analytic review of longitudinal cohort studies

Conduct problems trajectories and psychosocial outcomes: a systematic review and meta-analysis

Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis

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