Uncertainty Revealed by Delayed Responses During Olfactory Matching

Bhowmik, Rajdeep; Pardasani, Meenakshi; Mahajan, Sarang; Bhattacharjee, Anindya S.; Konakamchi, Sasank; Phadnis, Shambhavi; Musthafa, Thasneem; McGowan, Eleanor B.; Srikanth, Priyadharshini; Marathe, Shruti D.; Abraham, Nixon M.

doi:10.2139/ssrn.4241173

Cited by 2 publications

(4 citation statements)

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“…The replaceable stimulus delivery units makes the instrument useable under infectious disease conditions, as it prevents the cross-contamination. The graphical user interface of custom-written software is easy to operate and all parameters can be controlled and modified according to specific requirements ( Bhowmik et al, 2022 ). Therefore, our method can easily be implemented in clinics with minimal training for the personnel to operate the instrument.…”

Section: Discussionmentioning

confidence: 99%

“…A custom-built ten-channel OAM that delivers odors with high temporal precision is used for the present study ( Bhowmik et al, 2022 ). Odorized air (HEPA sterilized) passes through a glass funnel into an odor delivery unit.…”

Section: Methodsmentioning

confidence: 99%

“…This makes our method easily implementable in clinical settings and comparable with any other diagnostic tools ( Bhattacharjee et al, 2020 ). Further, our paradigm is amenable to modifications that can facilitate testing of olfactory matching skills with different time delays between the stimuli, that could prove useful in testing any alterations in working memory capacities of patients suffering from neurodegenerative disorders ( Bhowmik et al, 2022 ). A total of 11,683 behavioural readouts from 196 subjects (111 males and 85 females) participated in our olfactory fitness test using a custom-built olfactory action-meter.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Persistent olfactory learning deficits during and post-COVID-19 infection

Bhowmik¹,

Pardasani²,

Mahajan³

et al. 2023

Current Research in Neurobiology

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Persistent olfactory learning deficits during and post-COVID-19 infection

Bhowmik¹,

Pardasani²,

Mahajan³

et al. 2023

Current Research in Neurobiology

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“…Therefore, quantifying olfactory fitness of the ELA-affected population using precise methods may help in identifying and characterizing sensory and cognitive deficits at early stages and help in designing better treatment strategies [54][55][56][57].…”

Section: Discussionmentioning

confidence: 99%

Perceptual learning deficits mediated by somatostatin releasing inhibitory interneurons of olfactory bulb in an early life stress mouse model

Abraham

Pardasani²,

Ramakrishnan³

et al. 2023

Preprint

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Early life adversity (ELA) causes aberrant functioning of neural circuits affecting the health of an individual. While ELA-induced behavioural disorders resulting from sensory and cognitive disabilities can be assessed clinically, the neural mechanisms need to be probed using animal models by employing multi-pronged experimental methods. As ELA can alter perception, we investigated the effect of early weaning on murine olfaction. By implementing go/no-go odour discrimination paradigm, we observed olfactory learning and memory impairments in early life stressed (ELS) male mice. As olfactory bulb (OB) circuitry plays a critical role in odour learning, we studied the plausible changes in the OB of ELS mice. Lowered c-Fos activity in the external plexiform layer and a reduction in the number of dendritic processes of somatostatin-releasing, GABAergic interneurons (SOM-INs) in the ELS mice led us to hypothesize the underlying circuit. We recorded reduced synaptic inhibitory feedback on mitral/tufted (M/T) cells, in the OB slices from ELS mice, explaining the learning deficiency caused by compromised refinement of OB output. The role of SOM-INs was revealed by learning-dependent refinement of Ca2+ dynamics quantified by GCaMP6f signals. Further, the causal role of SOM-INs involving circuitry was investigated by optogenetic bi-directional modulation during odour discrimination learning. Photo-activating these neurons rescued ELA-induced learning deficits. Conversely, photo-inhibition caused learning deficiency in control animals, while it completely abolished the learning in ELS mice, confirming the adverse effects mediated by SOM-INs. Our results thus establish the role of specific inhibitory circuit in pre-cortical sensory area in orchestrating ELAdependent changes.

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Uncertainty Revealed by Delayed Responses During Olfactory Matching

Cited by 2 publications

References 0 publications

Persistent olfactory learning deficits during and post-COVID-19 infection

Persistent olfactory learning deficits during and post-COVID-19 infection

Perceptual learning deficits mediated by somatostatin releasing inhibitory interneurons of olfactory bulb in an early life stress mouse model

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