Uncommon Case of Oral Vancomycin Neurotoxicity With Sexual Dysfunction

The First Case of Vancomycin Induced Neurotoxicity and Literature Review

“…Finally, vancomycin-induced neurotoxicity is considered, and the correlation is 'very likely'. Ahmed Almohammadi reported a 57-year-old man who developed rare symptoms of nervous system poisoning during oral vancomycin treatment for clostridium difficile pseudomembranous colitis, including headache, altered state of consciousness, confusion of consciousness and somnolence with sexual dysfunction [19]. The patient did not take other drugs that cause neurotoxicity or may interact with vancomycin at the same time, so it was considered to be caused by oral vancomycin, and the correlation was 'possible'.…”

Detectable Vancomycin Stool Concentrations in Hospitalized Patients with Diarrhea Given Intravenous Vancomycin

“…Patients' electronic health records were screened for (1) IV vancomycin receipt for ≥48 h prior to stool collection, (2) ≥1 dose of IV vancomycin administered <24 h prior to stool collection (exception for hemodialysis patients with documented serum level), and (3) no oral vancomycin administration prior to stool collection. Factors associated with increased risk of vancomycin bowel penetration were collected and included renal function/renal replacement therapy, active bowel pathology (irritable bowel syndrome (IBS), diverticulitis, Crohn's disease, history of bariatric surgery, GI surgery within the last month, GI bleed within the last month), and active inflammatory states (active bowel pathology, active infection, shock as evidenced by vasopressor support, and active malignancy) [15,17,23,24]. This study was approved by the Committee for the Protection of Research Subjects at the University of Houston (CPHS000128).…”