False news can manipulate public opinion, stir up fear and hatred, and undermine the credibility of legitimate news sources. Although many studies have examined false news sharing, there has been no comprehensive, comparative, and computational investigation of the interventions that can reduce this harmful behavior. To do so, we introduce a novel experimental method, the Dynamic Semi-Integrative Approach (DSIA). DSIA involves testing multiple interventions, individual- and item-level moderators, and computational choice modeling (drift–diffusion modeling) in a single framework. By applying DSIA to false news, we find that warning labels and media literacy interventions are particularly effective at increasing news sharing accuracy, followed by a social norm intervention. Accuracy prompts were least effective. Intervention effects were consistent across individual- and item-level characteristics, such as age, analytical thinking, and the political-lean of news items, suggesting wide applicability. The interventions operated via different decision-making processes, suggesting that each intervention engages distinct mental processes to attenuate false news sharing. By developing and applying DSIA, we provide a uniquely detailed insight into false news interventions and establish DSIA as a promising, scalable approach for future experimental research.