Uncommon localization of amyloidosis in gallbladder: Description of a case and brief literature review

Tirotta, Daniela; Durante, Vittorio

doi:10.1016/s1665-2681(19)31574-1

Cited by 14 publications

(9 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…e wide spectrum of clinical manifestations can make amyloidosis a mimic for colorectal cancer, as patients often present with anemia, lower GI bleed, and/or weight loss [9]. Amyloid deposition in the gallbladder resulting in acute cholecystitis is uncommon and has been reported in a small number of cases [10,11]. is case reinforces the necessity of forming an extensive differential diagnosis to avoid a misdiagnosis or delayed treatment.…”

Section: Discussionmentioning

confidence: 90%

Secondary Amyloidosis Presenting as Ischemic Proctitis

Hashmi

Munis

Hoff

et al. 2021

Case Reports in Gastrointestinal Medicine

View full text Add to dashboard Cite

A 49-year-old man presented with abdominal pain and rectal bleeding for two days associated with a 50-pound unintentional weight loss. History was notable for hypertension, chronic kidney disease, obesity, gout, and acute cholecystitis status post cholecystectomy. Computed tomography (CT) of the abdomen and pelvis showed rectal wall thickening. Colonoscopy showed proctitis with superficial ulcerations. In the setting of renal insufficiency, malabsorption, and low-voltage QRS complexes on electrocardiogram (ECG), amyloidosis was considered in the differential diagnosis. Rectal and renal biopsies with subsequent retrospective staining of gallbladder tissue confirmed amyloid deposition. Gastrointestinal involvement of amyloidosis is relatively uncommon. Particularly, amyloid deposition in the gallbladder and rectum is very rare. The development of AA amyloidosis in our patient may have been related to gout, obesity, and the presence of a heterozygous complex variant for the MEFV (familial Mediterranean fever) gene. Awareness of this atypical presentation of amyloidosis is important, as additional staining of biopsy samples is necessary, and diagnosis allows for directed treatment.

show abstract

Section: Discussionmentioning

confidence: 90%

Secondary Amyloidosis Presenting as Ischemic Proctitis

Hashmi

Munis

Hoff

et al. 2021

Case Reports in Gastrointestinal Medicine

View full text Add to dashboard Cite

show abstract

“…This may one reason why cholecystic involvement in systemic amyloidosis is considered rare [9][10][11][12][13][14] . Although the severity of cardiac involvement in patients with only non-obstructive VD is considered mild to moderate, the presence of sporadic ATTR deposition in the heart, regardless of its amount, might be a risk factor for sudden cardiac death 8 .…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, because the frequency of sporadic ATTR amyloidosis, including ATTRwt and very late-onset hereditary ATTR, increases with age and it can affect systemic organs 7,8 , the frequency of the incidental discovery of ATTR deposition in cholecystectomy specimens should be increasing. However, cholecystic involvement in systemic amyloidosis, including ATTR amyloidosis, is considered extremely rare, and only a few cases have been reported [9][10][11][12][13][14][15] . As these reports contain only one or a small number of cases, the frequency and clinicopathological features of sporadic cholecystic ATTR deposition remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Effects of sporadic transthyretin amyloidosis frequently on the gallbladder and the correlation between amyloid deposition in the gallbladder and heart

Ichimata¹,

Hata²,

Nishida³

2021

Preprint

View full text Add to dashboard Cite

The aim of the study is to evaluate the clinicopathological features of cholecystic ATTR deposition in patients with cardiac involvement, investigate the correlation of amyloid deposition severity in the gallbladder and the heart, and compare its prevalence in the gallbladder and other organs. Fifty patients with sporadic ATTR amyloidosis were identified. Of these, we evaluated 15 patients who underwent gallbladder sampling accurately. Among 10 patients (67%) with cholecystic deposition, six exhibited detectable deposition in the hematoxylin and eosin-stained specimens, and all of them displayed obstructive vascular deposition (VD). The severity of gall bladder VD was statistically correlated with that of cardiac VD and atrial interstitial deposition (ID). Additionally, all patients exhibiting cholecystic ID displayed severe ventricular and atrial IDs. In visceral organs excluding the heart, amyloid deposition was commonly observed in the lungs (93%), followed by the gastrointestinal tract (47%‒80%), liver (60%), and periosteal tissues (53%). The involvement of gallbladder was prevalent and comparable to that of the gastrointestinal tract. Moreover, the severity of cholecystic deposition was correlated with that of cardiac deposition. Therefore, pathologists should be aware that sporadic ATTR amyloidosis is a common condition and should not be overlooked.

show abstract

“…Clinical images were not specific in any of the cases. For example, Kwon et al reported nodular wall thickening in the body of gallbladder which was enhanced by contrast-enhanced CT, whereas Kim et al and Tirotta et al reported mild thickening of the gallbladder on abdominal ultrasonography (11, 12, 14). In all 15 cases (including our case), a preoperative diagnosis of amyloid deposition in the gallbladder was difficult to make due to the nonspecific imaging findings of amyloid deposition in the gallbladder wall.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Acute Cholecystitis with Amyloidosis: A Case Report and Literature Review

et al. 2019

View full text Add to dashboard Cite

We present an extremely rare case of amyloid A (AA) deposition in the gallbladder and review the literature on similar cases. The patient was a 76-year-old man who had been diagnosed with mild bronchiectasis three years previously, who was admitted to the hospital with right upper quadrant pain and fever. Computed tomography revealed swelling and wall thickening of the gallbladder with a small gallstone. The patient was diagnosed with acute cholecystitis and cholelithiasis and underwent open cholecystectomy. A postoperative histological examination revealed extensive AA deposition in the gallbladder wall. Thus, the definitive diagnosis was acute cholecystitis with AA amyloidosis.

show abstract

Uncommon localization of amyloidosis in gallbladder: Description of a case and brief literature review

Cited by 14 publications

References 9 publications

Secondary Amyloidosis Presenting as Ischemic Proctitis

Secondary Amyloidosis Presenting as Ischemic Proctitis

Effects of sporadic transthyretin amyloidosis frequently on the gallbladder and the correlation between amyloid deposition in the gallbladder and heart

An Unusual Case of Acute Cholecystitis with Amyloidosis: A Case Report and Literature Review

Contact Info

Product

Resources

About