Uncommon patterns of presentation of leukemia

Vidal, C; Bloomfield, Clara D.

doi:10.1002/(sici)1099-1069(199903)17:1<11::aid-hon637>3.0.co;2-e

Cited by 10 publications

(8 citation statements)

References 51 publications

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“…[1][2][3][4][5] Pulse therapy with intravenous methylprednisolone is effective in cases refractory to oral steroid therapy. 3 In the present patient, because of the rapid progression of the skin lesion, a high dose (1 g) of methylprednisolone was chosen, and was markedly effective. Although up to 50% of PG patients were reported to experience relapses, 1 recurrence was not seen in the present patient.…”

Section: Discussionsupporting

confidence: 86%

“…1 The histologic features include a dense neutrophilic infiltrate of the tissue. [1][2][3][4] These clinical and histopathological features were also found in the present patient. The differential diagnoses of PG include bacterial cellulitis; atypical mycobacterial infections; and deep fungal mycoses, including blastomycosis, sporotrichosis, and cryptococcosis.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] Topical treatment is insufficient, especially in patients with associated cancers such as hematological malignancies. [1][2][3][4][5] Pulse therapy with intravenous methylprednisolone is effective in cases refractory to oral steroid therapy. 3 In the present patient, because of the rapid progression of the skin lesion, a high dose (1 g) of methylprednisolone was chosen, and was markedly effective.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 The diseases may be associated with a variety of systemic disorders such as inflammatory bowel diseases, rheumatoid arthritis, and various cancers, such as hematologic malignancies. [1][2][3][4][5] In the present report, we describe a large skin ulcer that developed in a patient with myelodysplastic syndrome (MDS). The lesion was eventually diagnosed as PG, and the patient was successfully treated with the systemic administration of corticosteroid hormone.…”

Section: Introductionmentioning

confidence: 99%

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Successful treatment of pyoderma gangrenosum that developed in a patient with myelodysplastic syndrome

Yamauchi

Ishida

Iwashima

et al. 2003

Journal of Infection and Chemotherapy

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Successful treatment of pyoderma gangrenosum that developed in a patient with myelodysplastic syndrome

Yamauchi

Ishida

Iwashima

et al. 2003

Journal of Infection and Chemotherapy

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“…But there are no guidelines about the radiation combined with chemotherapy treatment in this situation. Surgical resection, irradiation and chemotherapy may help control the progression, but the effectiveness remains controversial (13).…”

Section: Discussionmentioning

confidence: 99%

Extramedullary Relapse Presenting as Trigeminal Neuralgia and Diplopia after Allogeneic Hematopoietic Stem Cell Transplantation

Gong

Liang³

2011

Intern. Med.

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A 23-year-old woman presented with trigeminal neuralgia four months after hematopoietic stem cell transplantation (HSCT) for acute myeloblastic leukemia. No leukemic cells were found in the cerebrospinal fluid. Initial brain magnetic resonance imaging (MRI) did not reveal any abnormality. After symptom exacerbation with diplopia, second MRI showed an irregular mass at the right petrous apex, with uniform enhancement and a clear margin which was interpreted as a meningioma. The pathology and immunohistochemistry finally confirmed the diagnosis of granulocytic sarcoma. This case suggests that granulocytic sarcoma should be remembered as a very rare and a malignant pathology in the differential diagnosis of neurologic complications following HSCT.

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Leukapheresis and cranial irradiation in patients with hyperleukocytic acute myeloid leukemia: No impact on early mortality and intracranial hemorrhage

et al. 2007

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To assess the role of leukapheresis and cranial irradiation in reducing the incidence of intracranial hemorrhage (ICH) and early death in patients with hyperleukocytic acute myeloid leukemia (AML) and the impact of such treatment on survival. This study retrospectively analyzed the records of 75 patients with hyperleukocytic AML who had a white cell count over 100,000/lL. All patients had de novo AML except for two with therapy-related AML. Various factors were assessed for their impact on morbidity and mortality, particularly the role of pre-induction leukapharesis and cranial irradiation. The most significant risk factors for ICH were the presence of two or more symptoms of leukostasis (odds ratios [OR] 10.6, 95% CI: 2.67-42.02; P 5 0.001) and respiratory distress (OR 5.41, 95% CI: 1.44-20.32, P 5 0.012). The most significant risk factors for early death were age ‡ 65 (OR 4.21, 95% CI: 1.45-12.21, P 5 0.008), respiratory failure (OR 3.34, 95% CI: 1.24-9.50, P 5 0.018), and two or more symptoms (OR 3.50 95% CI: 1.16-10.52, P 5 0.026). Neither leukapheresis nor cranial irradiation were significantly associated with a decreased incidence of ICH (P 5 0.349 and 0.378, respectively). Leukapheresis had no significant influence on early death (P 5 0.367). The median survival patients receiving no pretreatment was 10.50 months (range 2.58-18.42) and for those receiving pretreatment 1.50 months (range 0.10-3.16; log-rank test, P 5 0.062). Leukapheresis and cranial irradiation do not improve survival or decrease the incidence of ICH in adults with hyperleukocytic AML. Am. J. Hematol. 82:976-980, 2007. V

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Uncommon patterns of presentation of leukemia

Cited by 10 publications

References 51 publications

Successful treatment of pyoderma gangrenosum that developed in a patient with myelodysplastic syndrome

Successful treatment of pyoderma gangrenosum that developed in a patient with myelodysplastic syndrome

Extramedullary Relapse Presenting as Trigeminal Neuralgia and Diplopia after Allogeneic Hematopoietic Stem Cell Transplantation

Leukapheresis and cranial irradiation in patients with hyperleukocytic acute myeloid leukemia: No impact on early mortality and intracranial hemorrhage

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