Uncommon Prostate Malignant Neoplasms

Abstract

Prostate adenocarcinoma is the most common prostate cancer; however, there are several other malignant neoplasms that radiologists should be familiar with. The histological classification of malignant prostate neoplasms includes epithelial tumors, mesenchymal tumors, neuroendocrine tumors, hematolymphoid tumors, and stromal tumors. Knowledge of the main clinical and prostate magnetic resonance imaging features of uncommon tumors beyond adenocarcinoma is important for radiologists to enlarge their diagnostic ability and guide referring physician regarding the appropriate patient workup. The aim of this review article is to (1) review the main anatomical and histological concepts of the prostate gland and (2) provide an overview of uncommon prostate malignant neoplasms, emphasizing the key clinical, pathological, and imaging findings that may help radiologists in their daily interpretation of prostate magnetic resonance imaging.

18F-PSMA-11 PET/MRI in Prostate Adenocarcinoma With Mucinous Features

“…Because of its rarity, there is only a few case reports on MRI findings of mucinous adenocarcinoma of the prostate. Unlike the usual prostate adenocarcinoma, which shows hypointensity on T2-weighted images, mucinous adenocarcinoma seems hyperintensity on T2-weighted images reflecting its large extracellular mucin content [5][6][7][8]. The T2 hyperintense tumor, especially the small tumor, may be difficult to recognize within the T2 hyperintense background of the peripheral zone 7,8.…”

“…Unlike the usual prostate adenocarcinoma, which shows hypointensity on T2-weighted images, mucinous adenocarcinoma seems hyperintensity on T2-weighted images reflecting its large extracellular mucin content. [5][6][7][8] The T2 hyperintense tumor, especially the small tumor, may be difficult to recognize within the T2 hyperintense background of the peripheral zone. 7,8 PSMA PET imaging of mucin-producing adenocarcinoma of the prostate has been rarely reported.…”