We focus on two aspects of CPT invariance in neutral-meson-antimeson (M 0M 0 ) mixing: 1. Tests of CPT invariance, using only the property of "lack of vacuum regeneration", which occurs as a part of the well-known LeeOehme-Yang (LOY) theory; 2. Methods for extracting the CPT-violating mixing parameter θ through explicit calculations by using the LOY-type theory fully. In the latter context, we demonstrate the importance of the C-even |M 0M 0 state. In particular, by measuring the time dependence of oppositesign dilepton events arising from decays of the C-even and C-odd |M 0M 0 states, θ may be disentangled from the parameters λ + andλ − characterizing violations of the ∆F = ∆Q rule. Furthermore, these two parameters may also be determined. The same is true if one uses like-sign dilepton events arising from only the C-even |M 0M 0 state.