Unconsented genetic testing in psychiatry: an (almost) no go?

Luykx, Jurjen J.; Spek, Rick van der; Veen, Sisco van; Lo-A-Foe, Wonnie; Giesbertz, Noor A. A.; Bredenoord, Annelien L.; Palmboom, Ger

doi:10.1016/s2215-0366(19)30206-8

Cited by 2 publications

(1 citation statement)

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“…These guidelines should encompass special considerations for situations involving people with psychiatric disorders, including those with impaired mental competence. For example, in such guidelines ethical case deliberation sessions may be suggested for situations where obtaining informed consent is not possible [ 172 ]. Procedures should be standardized and should aim to uphold human rights and bioethical principles, while at the same time accounting for cultural differences across the world.…”

Section: Recommendations To Overcome Barriers To Genomic Testingmentioning

confidence: 99%

Barriers to genetic testing in clinical psychiatry and ways to overcome them: from clinicians’ attitudes to sociocultural differences between patients across the globe

et al. 2022

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Genetic testing has evolved rapidly over recent years and new developments have the potential to provide insights that could improve the ability to diagnose, treat, and prevent diseases. Information obtained through genetic testing has proven useful in other specialties, such as cardiology and oncology. Nonetheless, a range of barriers impedes techniques, such as whole-exome or whole-genome sequencing, pharmacogenomics, and polygenic risk scoring, from being implemented in psychiatric practice. These barriers may be procedural (e.g., limitations in extrapolating results to the individual level), economic (e.g., perceived relatively elevated costs precluding insurance coverage), or related to clinicians’ knowledge, attitudes, and practices (e.g., perceived unfavorable cost-effectiveness, insufficient understanding of probability statistics, and concerns regarding genetic counseling). Additionally, several ethical concerns may arise (e.g., increased stigma and discrimination through exclusion from health insurance). Here, we provide an overview of potential barriers for the implementation of genetic testing in psychiatry, as well as an in-depth discussion of strategies to address these challenges.

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Section: Recommendations To Overcome Barriers To Genomic Testingmentioning

confidence: 99%