Uncontrolled Hypertension, Uncompensated Type II Diabetes, and Smoking Have Different Patterns of Vascular Dysfunction

Yugar‐Toledo, Juan Carlos; Tanus‐Santos, José Eduardo; Sabha, Maricene; Sousa, Márcio Gonçalves de; Cittadino, Máira; Tácito, Lúcia Helena Buonalumi; Moreno, Heitor

doi:10.1378/chest.125.3.823

Cited by 55 publications

(52 citation statements)

References 43 publications

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“…Yugar-Toledo et al [36] found that patients with diabetes showed an increase in plasma nitrite/nitrate levels, suggesting an association with excessive production and/or inactivation of NO. Ouviña et al [37] analyzed endothelial dysfunction and NO levels in patients with hypertension and in patients who suffered from both hypertension and diabetes.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Endothelial Dysfunction in Health and Disease; Using Various Parameters

Jalali

Phadke

2011

Ind J Clin Biochem

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Conditions like hypertension, atherosclerosis and diabetes are known to be the result of endothelial dysfunction which could begin early in the life of an individual. The markers of endothelial dysfunction studied in the present work are plasma hemoglobin, serum high sensitivity C-reactive protein (hsCRP) and plasma nitrite and nitrate. We studied the onset of endothelial dysfunction with increase in age as well as in disease condition like newly detected hypertensives and of hypertensive diabetic patients. The mean plasma hemoglobin and hsCRP values were found to increase with age. hsCRP and plasma hemoglobin levels were significantly higher in patient groups as compared to aged-matched controls. On the other hand nitrate and nitrite was significantly higher in patients who suffered from both diabetes and hypertension together and nitrate values were significantly lower in patients who suffered from hypertensive alone. Plasma hemoglobin and hsCRP are associated with endothelial dysfunction and increases both with age as well as in disease condition.

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Section: Discussionmentioning

confidence: 99%

Assessment of Endothelial Dysfunction in Health and Disease; Using Various Parameters

Jalali

Phadke

2011

Ind J Clin Biochem

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“…When a satisfactory position had been found, a special probe holder was fixed around the arm to secure the ultrasound transducer in the same position through the measurements. 7 A polyurethane cuff (Hokanson Inc., Bellevue, WA, USA) placed above the transducer was inflated around the arm to a pressure of 250 mm Hg for 5 min and then rapidly deflated. The increased brachial artery diameter was recorded from 45 to 120 s after cuff deflation.…”

Section: Endothelial Functionmentioning

confidence: 99%

“…7 Probably, arterial smooth muscle cell was still not affected because of a relative short time of hypertension diagnosis. The phosphodiesterase-5/cyclic guanosine monophosphate pathway, which is activated by the NTG administered, apparently has an important role in maintaining balance of the vascular reactivity function, as there is limited endothelial nitric oxide (NO) bioactivity.…”

Section: Nocturnal Dipping and Endothelial Function In Resistant Hypementioning

confidence: 99%

“…[5][6] Furthermore, as we have previously reported, endothelium-dependent and -independent arterial vasodilatation are clearly reduced in uncontrolled hypertensive patients compared with NT subjects. 7 However, the relation between the nocturnal drop in BP and endothelial function in CRH compared with UCRH patients has not been previously determined. Thus, the objective of this study was to determine whether the relation between nocturnal dipping status and vascular function in CRH and UCRH patients are similar.…”

Section: Introductionmentioning

confidence: 98%

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Non-dipping pattern relates to endothelial dysfunction in patients with uncontrolled resistant hypertension

et al. 2011

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Resistant hypertension (RHTN) includes both patients whose blood pressure (BP) is uncontrolled on three or more medications (uncontrolled RHTN (UCRH)) and patients whose BP is controlled with use of four or more drugs (controlled RHTN (CRH)). It is unknown whether endothelial function and nocturnal drop demonstrate a similar pattern in patients with CRH and UCRH. We examined circadian BP patterns and vascular function in these patients. In all, 40 CRH and 26 UCRH patients, and 25 normotensives underwent biochemical testing, ambulatory BP monitoring, determination of brachial artery responses to endothelial-dependent (flow-mediated; dilation (FMD)) and independent (nitroglycerin mediated) stimuli. The nighttime drop in systolic BP (SBP) and diastolic BP (DBP) was less pronounced in UCRH than in CRH (SBP, 1.9±1.6 versus 4.9 ± 1.7%; DBP, 7.5 ± 1.8 versus 10.9 ± 1.8%, UCRH and CRH, respectively; Po0.05). FMD was greater in control group compared with RHTN patients. Patients with UCRH had significantly impaired FMD compared with CRH (5.9 ± 2.3% versus 7.1 ± 5.1%; Po0.0001). Therefore, UCRH patients have less nocturnal dipping and a more impaired endothelial response compared with CRH patients. These findings suggest that important differences among patients with RHTN may allow identify subgroups with increased cardiovascular risk.

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“…The relationships between endothelial nitric oxide synthase polymorphisms and the formation of intracranial aneurysms in the Korean population 9 Therefore, altered NO levels have been reported to be related to many conditions and activities such as sepsis, 26 reproduction, 33 infection, 8 hypertension, 20 exercise, 21 diabetes, 44 hypoxia, 23 and cancer. 37 In particular, reduced NO levels can result in cardiovascular disease, carotid atherosclerosis, hypertension, and aortic aneurysm.…”

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confidence: 99%

The relationships between endothelial nitric oxide synthase polymorphisms and the formation of intracranial aneurysms in the Korean population

Kim

Baek

et al. 2011

FOC

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Object Some genetic factors are known to be associated with the formation of cerebral aneurysms in the Caucasian population. One of these factors is endothelial nitric oxide synthase (eNOS) gene polymorphisms. Endothelial nitric oxide synthase genes encode eNOS, which synthesizes NO from l-arginine. There continues to be controversy about the relationships between eNOS gene polymorphisms and the formation of intracranial aneurysms. In this study, the authors evaluated these relationships in the Korean population. Methods Three eNOS polymorphisms (eNOS 27VNTR, T786C, and G894T) were genotyped in 96 patients with ruptured aneurysms, 53 patients with unruptured aneurysms, and in 121 volunteers via polymerase chain reaction–restriction fragment length polymorphism analysis. Results The mean ages of the patients and healthy volunteers were 52.9 ± 12.3 years and 55.2 ± 9.1 years, respectively. The patient group was composed of 56 men and 93 women, and the healthy volunteer group was composed of 46 men and 75 women. Only the incidence of smoking history was significantly higher in the patient group than in the control group (p = 0.001). The genotypic frequencies for the 3 eNOS gene polymorphisms were in agreement with those predicted by Hardy-Weinberg equilibrium. There were no significant associations between the eNOS recessive models and the formation of an aneurysm. The authors found no genotypic differences between similar races among patients with aneurysms. Conclusions The present study shows that eNOS 27VNTR, T786C, and G894T polymorphisms cannot be used as indicators of the formation of intracranial aneurysms in Korean patients. To confirm these findings an additional analyses might need to be performed using a larger sample size. There were no differences in the genotypic distributions and allelic frequencies between similar races among patients with aneurysms, which were the same in previously reported normal populations.

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Uncontrolled Hypertension, Uncompensated Type II Diabetes, and Smoking Have Different Patterns of Vascular Dysfunction

Cited by 55 publications

References 43 publications

Assessment of Endothelial Dysfunction in Health and Disease; Using Various Parameters

Assessment of Endothelial Dysfunction in Health and Disease; Using Various Parameters

Non-dipping pattern relates to endothelial dysfunction in patients with uncontrolled resistant hypertension

The relationships between endothelial nitric oxide synthase polymorphisms and the formation of intracranial aneurysms in the Korean population

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