Unconventional high-value products from microalgae: A review

Abu‐Ghosh, Said; Dubinsky, Zvy; Verdelho, Vítor; Iluz, David

doi:10.1016/j.biortech.2021.124895

Cited by 83 publications

(30 citation statements)

References 113 publications

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“…It exhibits higher antioxidant activity than β-carotene in attenuating oxidative damage and preventing damage to lipid bilayers [ 35 ]. The global market of fucoxanthin was USD 600 million in 2020 and is anticipated to reach USD 780 million by the end of 2025, growing at a compound annual growth rate of 6% between 2020 and 2025 [ 36 ]. It was first commercially produced by Algatechnologies Ltd. in 2018 with a trademark Fucovital ® mainly employed in bodyweight management products.…”

Section: Bioactive Compoundsmentioning

confidence: 99%

“…The balanced diet ratio of polyunsaturated fatty acids to saturated fatty acids recommended by the World Health Organization (WHO) and the FDA should be above 0.4 and prescribed intake should be 0.2–0.3 g DHA and EPA per day for a healthy individual [ 41 ]. Dihomo-γ-linolenic acid (DGLA), a trace amount long chain PUFA is important in developing infant formulations [ 36 ]. Chaetoceros calcitrans , Crythecodinium cohnii , Isochrysis galbana , Monodus subterraneus , Nannochloropsis sp., Pavlova salina , Phaeodactylum tricornutum , and Porphyridium cruentum are some of the PUFAs producing microalgal species [ 42 , 43 ].…”

Section: Bioactive Compoundsmentioning

confidence: 99%

“…Mycosporine amino acids (MAA) and polysaccharides are widely employed in skin photoaging, and their efficiency was tested in HeLa cervical adenocarcinoma and B16-F1 murine skin melanoma of human cell lines [ 84 ]. MAAs have high efficiency in absorbing UV radiation (310–360 nm) with molar absorptivity ranging from 2.8 to 5.0 × 10 4 M −1 cm −1 [ 36 ]. Pentapharm (Basel, Switzerland), Blue Retinol TM , Protulines, Exsymol S.A.M., (Monaco, Europe), and Helioguard ® 365 and SILIDINE ® (Greentech, New Jersey, USA) are popular anti-aging skin products extracted from Nannochloropsis oculata , Porphyridium cruentum , and Arthrospira sp.…”

Section: Therapeutical Function Of Microalgaementioning

confidence: 99%

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Microalgal Cell Biofactory—Therapeutic, Nutraceutical and Functional Food Applications

Kiran

Mohan

2021

Plants

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Microalgae are multifaceted photosynthetic microorganisms with emerging business potential. They are present ubiquitously in terrestrial and aquatic environments with rich species diversity and are capable of producing significant biomass. Traditionally, microalgal biomass is being used as food and feed in many countries around the globe. The production of microalgal-based bioactive compounds at an industrial scale through biotechnological interventions is gaining interest more recently. The present review provides a detailed overview of the key algal metabolites, which plays a crucial role in nutraceutical, functional foods, and animal/aquaculture feed industries. Bioactive compounds of microalgae known to exhibit antioxidant, antimicrobial, antitumor, and immunomodulatory effects were comprehensively reviewed. The potential microalgal species and biological extracts against human pathogens were also discussed. Further, current technologies involved in upstream and downstream bioprocessing including cultivation, harvesting, and cell disruption were documented. Establishing microalgae as an alternative supplement would complement the sustainable and environmental requirements in the framework of human health and well-being.

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Section: Bioactive Compoundsmentioning

confidence: 99%

Section: Bioactive Compoundsmentioning

confidence: 99%

Section: Therapeutical Function Of Microalgaementioning

confidence: 99%

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Microalgal Cell Biofactory—Therapeutic, Nutraceutical and Functional Food Applications

Kiran

Mohan

2021

Plants

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“…As they are photosynthetic microorganisms, they might provide simpler cultivation facilities and easier processes (no sterilization required, low contamination potential, etc.) for the production of biomass and the subsequent biomolecules [1][2][3]. More recently, microalgae have attracted attention for the production of carbohydrates (polysaccharides) and as a potentially renewable source for various applications in the food and chemical industry [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Production of Arthrospira (Spirulina) platensis Enriched in β-Glucans through Phosphorus Limitation

et al. 2021

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(1) Background: Arthrospira (commonly known as Spirulina) is an edible cyanobacterium that is produced worldwide as a food supplement owing to its high nutritional value. Arthrospira displays strong potential as an important ingredient in the development of novel functional foods. Polysaccharides from Arthrospira are biologically active compounds and hence there is interest in producing biomass rich in carbohydrates. (2) Methods: A. platensis was cultivated under different degrees of phosphorus limitation in order to trigger the accumulation of carbohydrates. The biomass was then characterized in terms of its content of α- and β-glucans, total dietary fiber and monosaccharide profile. Fourier-transform infrared spectroscopy (FTIR) was used for the rapid analysis of the main biomass components. (3) Results: Phosphorus limitation resulted in an increase in carbohydrates (from 23% up to 65% dry biomass) of which 4–12% (in relation to the dry biomass) was α-glucans and 20–34% was 1.3:1.6 β-glucans, while 1.4:1.6 β-glucans were not detected. Total dietary fibers ranged from 20–32% (of dry biomass), whereas among the carbohydrates, the predominant monosaccharide was glucose (>95%). FTIR performed well when applied as a prediction tool for the main biomass components. (4) Conclusions: Since β-glucans are of particular interest as biologically active compounds, this study demonstrates that phosphorus-limited A. platensis could be a potential ingredient for the development of novel functional foods.

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“…Moreover, microalgae are gaining momentum as a novel source for the development and production of functional foods/feeds. This is because they synthesize various bioactive metabolites such as polysaccharides [11,12], polyunsaturated fatty acids [13,14], antioxidant compounds [15,16], vitamins [17,18], etc., that have proven health promoting properties, and therefore, they could be used as ingredients to develop novel functional foods/feeds [19][20][21][22][23][24]. Besides these nutritional compounds, there is also a huge potential to produce diverse intracellular or extracellular high-value products from microalgae including enzymes, such as cellulases, proteases, galactosidases, lipases, phosphatases, etc., which might have diverse applications in food or chemistry sectors [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Bioprocess Optimization for the Production of Arthrospira (Spirulina) platensis Biomass Enriched in the Enzyme Alkaline Phosphatase

Μάρκου

2021

Bioengineering

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The enzyme alkaline phosphatase (ALP) is gaining interest because it exerts bioactive properties and may be a potentially important therapeutic agent for many disorders and diseases. Microalgae are considered an important novel source for the production of diverse bio-compounds and are gaining momentum as functional foods/feeds supplements. So far, studies for the production of ALP are limited to mammalian and partly to some heterotrophic microbial sources after its extraction and/or purification. Methods: Arthrospira was cultivated under P-limitation bioprocess and the effect of the P-limitation degree on the ALP enrichment was studied. The aim of this work was to optimize the cultivation of the edible and generally-recognized-as-safe (GRAS) cyanobacterium Arthrospira platensis for the production of single-cell (SC) biomass enriched in ALP as a potential novel functional diet supplement. Results: The results revealed that the relationship between intracellular-P and single-cell alkaline phosphatase (SC-ALP) activity was inverse; SC-ALP activity was the highest (around 50 U g−1) when intracellular-P was the lowest possible (around 1.7 mg-P g−1) and decreased gradually as P availability increased reaching around 0.5 U g−1 in the control cultures. Under the strongest P-limited conditions, a more than 100-fold increase in SC-ALP activity was obtained; however, protein content of A. platensis decreased significantly (around 22–23% from 58%). Under a moderate P-limitation degree (at intracellular-P of 3.6 mg-P g−1), there was a relatively high SC-ALP activity (>28 U g−1) while simultaneously, a relative high protein content (46%) was attained, which reflects the possibility to produce A. platensis enriched in ALP retaining though its nutritional value as a protein rich biomass source. The paper presents also results on how several parameters of the ALP activity assay, such as pH, temperature etc., and post-harvest treatment (hydrothermal treatment and biomass drying), influence the SC-ALP activity.

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Unconventional high-value products from microalgae: A review

Cited by 83 publications

References 113 publications

Microalgal Cell Biofactory—Therapeutic, Nutraceutical and Functional Food Applications

Microalgal Cell Biofactory—Therapeutic, Nutraceutical and Functional Food Applications

Production of Arthrospira (Spirulina) platensis Enriched in β-Glucans through Phosphorus Limitation

Bioprocess Optimization for the Production of Arthrospira (Spirulina) platensis Biomass Enriched in the Enzyme Alkaline Phosphatase

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