Unconventional Treatments for Vitiligo: Are They (Un) Satisfactory?

Gianfaldoni, Serena; Tchernev, Georgi; Lotti, Jacopo; Wollina, Uwe; Satolli, Francesca; Rovesti, Miriam; França, Katlein; Lotti, Torello

doi:10.3889/oamjms.2018.038

Cited by 24 publications

(24 citation statements)

References 48 publications

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“…The repigmentation in vitiligo is believed to be linked to a synergistic effect of all the antioxidant action of these herbal bio-actives. The availability of any new treatment that can reduce the use of UVB from high to low, and still be efficacious, is of immense benefit to both patients and treating physicians [21], [22], [23], [24], [25], [26], [27], [28], [29].…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Vitiligo Vietnamese Patients with VitilinexÂ® Herbal Bio-Actives in Combination with Phototherapy

Van¹,

Minh²,

Huu³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND:Vitiligo is an acquired pigmentary disease, that causes progressive loss of melanocytes, resulting in hypopigmented skin patches. Current treatments aim at stopping the disease progression and achieving repigmentation of the amelanotic areas. Corticosteroids, surgery, topical immunomodulators, total depigmentation of normal pigmented skin and phototherapy are current treatment options for vitiligo although phototherapy remains the treatment of choice. There is no documented evidence that herbal bio-active products may also be effective treatment options for vitiligo.AIM:This study aimed to investigate the efficacy and safety of Vitilinex® (herbal bio- actives) alone and in combination with UVB narrowband (311 nm) phototherapy, in the treatment of localised stable or active forms of vitiligo.MATERIAL AND METHODS:Sixty two subjects with mean age 34.5 years (range: 18-58 years) with mild to moderate vitiligo, consisting of 36 females and 26 males were randomly divided into three treatment groups – Group A (13 females, 10 males) treated with Vitilinex® alone; Group B (12 females, 11 males) were treated with Vitilinex® in combination with narrowband UVB (311 nm) phototherapy for 15 seconds, using a handheld lamp and Group C (8 females, 8 males) were treated with nbUVB (311 nm) phototherapy alone, for 15 seconds over a 12-week period.RESULTS:In Group A, 9 patients (39%) achieved outstanding improvement with a re-pigmentation rate higher than 75%, with 2 patients experiencing total repigmentation. 6 patients (26%) had marked improvement with a repigmentation rate between 50-75% while 5 patients (22%) showed a moderate response between 25-50% re-pigmentation rate. 3 patients (13%) had minimal or no improvement. In Group B, 16 patients (69.5%) achieved outstanding improvement with a re-pigmentation rate higher than 75%, with 12 patients experiencing total re-pigmentation. 4 patients (17.5 %) achieved a marked improvement with a re-pigmentation rate between 50-75%; 2 patients (8.7%) showed a moderate response with a re-pigmentation rate between 25-50%. 1 (4.3%) patient had minimal or no improvement. In Group C, 6 patients (37.5%) achieved a re-pigmentation rate higher than 75%, with 2 patients experiencing total re-pigmentation. 4 patients (25%) achieved marked improvement with a re-pigmentation rate between 50-75% while 3 patients (18.75%) had a re-pigmentation rate between 25-50%. 3 patients (18.75%) had minimal or no improvement.CONCLUSION:Vitilinex® herbal bio-actives in combination with nbUVB is a more effective treatment option for vitiligo with 87% of the patients achieving a re-pigmentation rate higher than 50%, compared to Vitilinex® alone (65%) or nbUVB alone (62.5%).

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Section: Discussionmentioning

confidence: 99%

Successful Treatment of Vitiligo Vietnamese Patients with VitilinexÂ® Herbal Bio-Actives in Combination with Phototherapy

Van¹,

Minh²,

Huu³

et al. 2019

Open Access Maced J Med Sci

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“…1 Some conventional therapies, including medical and surgical approaches, or unconventional therapies, such as phototherapy, are used in the management of this pathological condition. [3][4][5] Additionally, many tissue grafting techniques are available, but suction blister epidermal grafting and mini-punch grafting are the most widely utilized. 6 In recent years, the Rigenera â micrografting technology (Human Brain Wave, Turin, Italy) has been developed, by using the Rigeneraconsâ approved medical device, a new clinical approach to obtain autologous micrografts from mechanical disaggregation of small fragments of the patient's own tissue.…”

Section: Introductionmentioning

confidence: 99%

Effects of autologous micrografts on stable bilateral vitiligo: A focus on hand lesions

Menchini¹,

Astarita

2020

The Journal of Dermatology

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Vitiligo is an autoimmune skin disorder characterized by depigmented patches of the skin associated with, among several factors, dysregulation and death of melanocytes. Currently, the treatment of vitiligo is based both on the arrest of the progression of active disease and on the stimulation of the skin repigmentation. The aim of this study was to assess the effects of autologous micrografts and narrowband ultraviolet B (NBUVB) phototherapy for skin repigmentation of patients with bilateral stable vitiligo. Autologous micrografts are derived from mechanical disaggregation of small pieces of the patient's own skin, while phototherapy is a strategy treatment already used. Twenty patients with stable bilateral vitiligo were treated, showing a mean percentage rate of 59.1% at baseline. Combined treatment by autologous micrografts and NBUVB was performed only on the lesions of the hands, and the clinical follow up was performed after 3 and 6 months by photographs taken under Wood's light. After 6 months, we classed 100% of patients as responders. We also reported a mean of repigmentation rate of 36.7% after 3 months and 64.6% after 6 months of treatment. In particular, six of the 20 patients reached a marked repigmentation rate (75-100%), four moderate (51-75%) and 10 mild (26-50%). No adverse effects were observed and no drugs were administrated as co-adjuvant therapy. These results are suggestive of a potential wide use of autologous micrografts associated with NBUVB phototherapy for the treatment of stable vitiligo.

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“…Ultraviolet radiation is commonly used to induce melanin production with the optional addition of various photosensitizers, such as psoralens [29][30][31] . Several compounds can seemingly increase the production of tyrosine, including phenylalanine, its precursor amino acid [32] . Efforts to increase the activity of tyrosine and other Janus kinases (JAK) led to the unanticipated finding that JAK inhibitors were able to achieve partial re-pigmentation of vitiligo affected skin areas.…”

Section: Introductionmentioning

confidence: 99%

Vitiligo Treated by Soaking in an Earth Pond Containing KELEA Activated Water

Sandwell¹

2020

AJODRR

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Vitiligo completely regressed in two patients who spent several hours for each of three consecutive days in a pond that contains water with a heightened quantity of a non-thermal activity attributed to a natural force called KELEA (Kinetic Energy Limiting Electrostatic Attraction). KELEA is further defined as the source of cellular energy, which comprises the alternative cellular energy (ACE) pathway. The ACE pathway differs from the cellular energy obtained from food metabolism. It is expressed as an added dynamic (kinetic) quality of the body's fluids. The body utilizes the ACE pathway in both chemical and electrical cellular reactions, including the recovery and regenerative processes following cellular damage. The ACE pathway supports the higher levels of brain functioning including the likelihood of improving upon the presumed KELEA receiving capacity of the brain. The ACE pathway can also limit the triggering and maintenance of the inflammatory response. Each of these activities is presumably involved in the clinical regression of the vitiligo in the two patients. Enhancing the ACE pathway may provide an effective therapeutic approach for many patients with vitiligo.

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Unconventional Treatments for Vitiligo: Are They (Un) Satisfactory?

Abstract: The authors show a brief overview of the vitiligo’s unconventional therapies. A part for well-documented effectiveness of L-phenylalanine, PGE2 and antioxidant agents in the treatment of vitiligo, for the other therapeutical approaches more investigations are needed.

Cited by 24 publications

References 48 publications

Successful Treatment of Vitiligo Vietnamese Patients with VitilinexÂ® Herbal Bio-Actives in Combination with Phototherapy

Successful Treatment of Vitiligo Vietnamese Patients with VitilinexÂ® Herbal Bio-Actives in Combination with Phototherapy

Effects of autologous micrografts on stable bilateral vitiligo: A focus on hand lesions

Vitiligo Treated by Soaking in an Earth Pond Containing KELEA Activated Water

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