Uncoupled poroelastic and intrinsic viscoelastic dissipation in cartilage

Han, Guebum; Hess, Cole; Eriten, Melih; Henak, Corinne R.

doi:10.1016/j.jmbbm.2018.04.024

Cited by 39 publications

(14 citation statements)

References 40 publications

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“…In the example, we set the specimen's cross‐sections as 20 cm by 20 cm falling within the typical range of laboratory setups for rocks (from several cm to tens of cm). In biomechanics, articular cartilage and bone samples are usually on the scale of millimeter, 76,77 and tendons even in nanoscale 14 . Measurements have shown that rock's mechanical properties vary with specimen's size 78–80 .…”

Section: Discussionmentioning

confidence: 99%

Fundamental solutions to the transversely isotropic poroelastodynamics Mandel's problem

Liu

2021

Num Anal Meth Geomechanics

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Many geomaterials, such as shale, and biomaterials, including human bone and cartilage, are anisotropic. Understanding the dynamic responses of such anisotropic porous media is essential in field operations and laboratory measurements. This paper presents analytical solutions to the transversely isotropic poroelastodynamics Mandel's problem, using the Fourier transform method and Cardano formula to solve coupled six‐order partial differential equations. Potential applications of the solutions include explaining coupled fluid‐solid dynamics, validating numerical algorithms, and interpreting dynamic responses of anisotropic porous media. As an example, we apply the solutions to simulate a fluid‐saturated transversely isotropic Trafalgar shale specimen subjected to harmonic excitation. The simulation shows that pore pressure builds up as frequency increases. The buildup occurs at a lower frequency for a lower horizontal permeability. The amount of pore pressure buildup due to the Mandel‐Cryer effect is sensitive to material anisotropy. The porous material's effective stiffness reaches its periodic minimum and maximum at the resonant and anti‐resonant frequencies controlled by mechanical anisotropy and pore fluid.

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Section: Discussionmentioning

confidence: 99%

Fundamental solutions to the transversely isotropic poroelastodynamics Mandel's problem

Liu

2021

Num Anal Meth Geomechanics

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“…Compressive strain rate is often associated with fluid flow in cartilage, which subjects chondrocytes to shear, thus inducing metabolic flux 48,49 . Though bulk strain rates in the present study were physiological, resulting in minimal fluid flow across the whole tissue, metabolic imaging evaluated a local region of cartilage just beneath a cut sample edge where fluid flow may have played a nontrivial role in the observed metabolic changes 50 . Further, additional research could clarify whether the loads applied in this study, which were highly unlikely to be injurious, could induce a healthy inhibitory effect on anabolic activity as a physiological process by which metabolic homeostasis is maintained 51,52 .…”

Section: Discussionmentioning

confidence: 99%

Real-time optical redox imaging of cartilage metabolic response to mechanical loading

Walsh

Skala

Henak

2019

Osteoarthritis and Cartilage

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Objective: Metabolic dysregulation has recently been identified as a key feature of osteoarthritis. Mechanical overloading has been postulated as a primary cause of this metabolic response. Current methods of real-time metabolic activity analysis in cartilage are limited and challenging. However, optical redox imaging leverages the autofluorescence of co-enzymes NAD(P)H and FAD to provide dye-free real-time analysis of metabolic activity. This technique has not yet been applied to cartilage. This study aimed to assess the effects of a compressive load on cartilage using optical redox imaging. Method: Cartilage samples were excised from porcine femoral condyles. To validate this imaging modality in cartilage, glycolysis was inhibited via 2-deoxy-D-glucose (2DG) and oxidative phosphorylation was inhibited by rotenone. Optical redox images were collected pre-and post-inhibition. To assess the effects of mechanical loading, samples were subjected to a compressive load and imaged for approximately 30 min. Load and strain parameters were determined using high-speed camera images in Matlab. A range of loading magnitudes and rates were applied across samples. Results: 2DG and rotenone demonstrated the expected inhibitory effects on fluorescence intensity in the channels corresponding to NAD(P)H and FAD, respectively. Mechanical loading induced an increase in NAD(P)H channel fluorescence which subsided by 30 min post-loading. Magnitude of loading parameters had mixed effects on metabolites. Conclusions: Optical redox imaging provides an opportunity to assess real-time metabolic activity in cartilage. This approach revealed a metabolic response to a single load and can be used to provide insight into the role of metabolism in mechanically-mediated cartilage degradation.

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“…Hydration and dehydration are factors that affect the dissipation of pressure energy [ 48 ]. AC dissipation response is analyzed by uncoupling poroelastic and intrinsic viscoelastic mechanisms.…”

Section: Mechanical Characteristics Of Articular Cartilagementioning

confidence: 99%

“…AC dissipation response is analyzed by uncoupling poroelastic and intrinsic viscoelastic mechanisms. In the dehydration state, energy dissipation reduction presents the essence of hydration in both poroelastic and viscoelastic functionality [ 48 ]. Several elements affect the mechanical properties of AC; however, researchers have circumnavigated through the complexities using customized techniques.…”

Section: Mechanical Characteristics Of Articular Cartilagementioning

confidence: 99%

Articular and Artificial Cartilage, Characteristics, Properties and Testing Approaches—A Review

2021

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The design and manufacture of artificial tissue for knee joints have been highlighted recently among researchers which necessitates an apt approach for its assessment. Even though most re-searches have focused on specific mechanical or tribological tests, other aspects have remained underexplored. In this review, elemental keys for design and testing artificial cartilage are dis-cussed and advanced methods addressed. Articular cartilage structure, its compositions in load-bearing and tribological properties of hydrogels, mechanical properties, test approaches and wear mechanisms are discussed. Bilayer hydrogels as a niche in tissue artificialization are presented, and recent gaps are assessed.

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Uncoupled poroelastic and intrinsic viscoelastic dissipation in cartilage

Cited by 39 publications

References 40 publications

Fundamental solutions to the transversely isotropic poroelastodynamics Mandel's problem

Fundamental solutions to the transversely isotropic poroelastodynamics Mandel's problem

Real-time optical redox imaging of cartilage metabolic response to mechanical loading

Articular and Artificial Cartilage, Characteristics, Properties and Testing Approaches—A Review

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