Uncoupler-reversible inhibition of mitochondrial ATPase by metal chelates of bathophenanthroline. II. comparison with other inhibitors

Carlsson, Christine; Ernster, Lars

doi:10.1016/0005-2728(81)90247-4

Cited by 7 publications

(2 citation statements)

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“…BPh 3 -Ni 2ϩ and BPh 3 -Ru 2ϩ are equally efficient inhibitors in the uncoupler-reversible inhibition of MF 1 (63,65). Moreover, BPh 3 -Fe 2ϩ protects F 1 from cold-induced dissociation and light-induced inactivation by Rose bengal in an uncoupler-reversible manner (64). The related chelates 4,4-diphenyl-2,2-bipyridine and 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine with Fe 2ϩ also inhibit MF 1 , but with weaker inhibitory potencies than BPh 3 -metal chelates (63).…”

Section: Other Organic Cationsmentioning

confidence: 97%

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ATP Synthase and the Actions of Inhibitors Utilized To Study Its Roles in Human Health, Disease, and Other Scientific Areas

Hong

Pedersen

2008

Microbiol Mol Biol Rev

276

302

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SUMMARY ATP synthase, a double-motor enzyme, plays various roles in the cell, participating not only in ATP synthesis but in ATP hydrolysis-dependent processes and in the regulation of a proton gradient across some membrane-dependent systems. Recent studies of ATP synthase as a potential molecular target for the treatment of some human diseases have displayed promising results, and this enzyme is now emerging as an attractive molecular target for the development of new therapies for a variety of diseases. Significantly, ATP synthase, because of its complex structure, is inhibited by a number of different inhibitors and provides diverse possibilities in the development of new ATP synthase-directed agents. In this review, we classify over 250 natural and synthetic inhibitors of ATP synthase reported to date and present their inhibitory sites and their known or proposed modes of action. The rich source of ATP synthase inhibitors and their known or purported sites of action presented in this review should provide valuable insights into their applications as potential scaffolds for new therapeutics for human and animal diseases as well as for the discovery of new pesticides and herbicides to help protect the world's food supply. Finally, as ATP synthase is now known to consist of two unique nanomotors involved in making ATP from ADP and Pi, the information provided in this review may greatly assist those investigators entering the emerging field of nanotechnology.

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Section: Other Organic Cationsmentioning

confidence: 97%

“…Octahedral bathophenanthroline (BPh 3 )-metal chelates inhibit MF 1 in an uncoupler-reversible fashion (63)(64)(65)315). They bind to the ATP synthase ␤ subunit and form a complex with a stoichiometic ratio of 3 mol BPh 3 -Me 2ϩ /mol F 1 .…”

Section: Other Organic Cationsmentioning

confidence: 99%