Uncoupling of <i>in vivo</i> torque production from EMG in mouse muscles injured by eccentric contractions

Warren, Gordon L.; Ingalls, Christopher P.; Shah, Shree J.; Armstrong, R. B.

doi:10.1111/j.1469-7793.1999.609ac.x

Cited by 86 publications

(108 citation statements)

References 28 publications

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“…However, the link between the histopathology and strength loss is not strong, either temporally or quantitatively. The greatest strength deficit occurs immediately after an injurious bout of exercise, 4,12,14,21 but histopathology at the light microscopic level is not apparent in muscle cross-sections until two to four days later when inflammatory cells have invaded the tissue. 1,14,16 A quantitative dissociation of the strength loss from histopathology is a common observation in the literature.…”

Section: Damage To Force-generating or Force-transmitting Structuresmentioning

confidence: 99%

“…21 Finally, we have conducted a preliminary investigation of t-tubular membrane function in injured muscle. T-tubular membrane function in the injured muscle appeared normal when probed with a high extracellular concentration of potassium used to induce contraction by depolarizing plasmalemmal and t-tubular membranes.…”

Section: Failure To Activate Intact Force-generating Structuresmentioning

confidence: 99%

“…Peak torque production during two 150-contraction protocols. Data are from Warren et al 21 and were acquired using our model for inducing injury to the anterior crural muscles of intact, anesthetized mice. One group of mice performed 150 maximal eccentric contractions (open circles) and a second group performed 150 maximal concentric contractions (filled circles).…”

mentioning

confidence: 99%

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What Mechanisms Contribute to the Strength Loss That Occurs During and in the Recovery from Skeletal Muscle Injury?

Warren

Ingalls

Lowe

et al. 2002

J Orthop Sports Phys Ther

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106

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In the workplace or on the athletic field, muscle strength can be decreased by 50% or more following performance of a relatively few high-force, eccentric contractions. The strength loss can be prolonged, taking a month or more for complete recovery. It is important to understand the cause(s) of the strength loss so we can develop means of preventing or attenuating this loss. The cellular-level mechanisms explaining the loss of strength following contraction-induced muscle injury remain controversial. The traditional thought is that initial strength loss is due solely to damage to force-bearing structures within the muscle, as evidenced by histopathology. In addition, inflammation in the days following injury is commonly thought to exacerbate the strength loss. We present data to the contrary. Recent data show that most of the early strength loss results from a failure of excitation-contraction coupling processes and that a slow loss of contractile protein in the days following injury prolongs the time for recovery. J Orthop Sports Phys Ther 2002;32:58-64.

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Section: Damage To Force-generating or Force-transmitting Structuresmentioning

confidence: 99%

Section: Failure To Activate Intact Force-generating Structuresmentioning

confidence: 99%

mentioning

confidence: 99%

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What Mechanisms Contribute to the Strength Loss That Occurs During and in the Recovery from Skeletal Muscle Injury?

Warren

Ingalls

Lowe

et al. 2002

J Orthop Sports Phys Ther

Self Cite

106

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show abstract

“…Reductions in myofibrillar proteins 5-14 days postinjury are common in wild-type mice (16,18), but until this study, the extent to which contractile protein loss contributes to force decrements after contraction-induced injury in dystrophic muscle was unclear. Low tetanic force immediately and up to 3 days after eccentric contractions has been attributed to aspects of excitation-contraction uncoupling in wild-type mice (16,46) and may play a role in the early strength deficits in mdx mice as well (47).…”

Section: Rapid Recovery Of Dystrophic Musclementioning

confidence: 99%

Adaptive strength gains in dystrophic muscle exposed to repeated bouts of eccentric contraction

Call¹,

Eckhoff²,

Baltgalvis

et al. 2011

Journal of Applied Physiology

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“…While we lack histological evidence, our mechanical findings suggest improved muscle function with intramuscular injection of MSCs. Isometric peak torque is a non-invasive in vivo physiologic assessment of function that allows for longitudinal testing [31,32]. Undeniably, in vivo assays for muscle function have limitations.…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal Stem Cells Improve Muscle Function Following Single Stretch Injury: A Preliminary Study

Brickson

Meyer

Saether

et al. 2016

JFMK

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Abstract:Stem cells have shown promise as a therapeutic intervention by enhancing skeletal muscle regeneration following muscle injury. The purpose of this study was to determine the effect of mouse mesenchymal stem cells (MSCs) on muscle function following a single stretch injury in the calf muscle of C57BL/67 mice. A custom isokinetic device was used to induce a single stretch injury. An intramuscular injection of MSCs or saline was administered three days post-injury. Mechanical testing to measure peak isometric joint torque in vivo was done immediately and at seven or 14 days post-injury. Susceptibility to reinjury was assessed in the soleus muscle using an in situ repeated eccentric contraction (ECC) protocol. In vivo isometric torque of the plantar flexors dropped immediately following stretch injury by 50%. Treatment with MSCs attenuated the torque deficit at seven days, while there were no differences in torque deficit between groups at 14 days. In situ ECC testing of the soleus showed a significant specific force drop following injury, with the MSC group demonstrating a protective effect at seven and 14 days. These results demonstrate transient improvement in isometric torque and reduced susceptibility to reinjury following single stretch injury with intramuscular injection of MSCs.

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Uncoupling of in vivo torque production from EMG in mouse muscles injured by eccentric contractions

Cited by 86 publications

References 28 publications

What Mechanisms Contribute to the Strength Loss That Occurs During and in the Recovery from Skeletal Muscle Injury?

What Mechanisms Contribute to the Strength Loss That Occurs During and in the Recovery from Skeletal Muscle Injury?

Adaptive strength gains in dystrophic muscle exposed to repeated bouts of eccentric contraction

Mesenchymal Stem Cells Improve Muscle Function Following Single Stretch Injury: A Preliminary Study

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