Uncovering a Tumor Suppressor for Triple-Negative Breast Cancers

Abstract

In our discussion of the role of tyrosine kinase networks in the above Preview, we inadvertently omitted an important contribution by Roger Daly and colleagues (Hochgrä fe et al., 2010). In this report, the authors demonstrate that there is an enrichment of tyrosine phosphorylation of Src family and receptor tyrosine kinases in triple-negative breast cancer cell lines and show that inhibition of multiple tyrosine kinases is an effective strategy against these cancers. These findings presage and complement the finding by Westbrook and colleagues that PTPN12 loss in triple-negative breast cancers results in activation of tyrosine kinase networks (Sun et al., 2011). We regret any misunderstanding caused by this omission.