Uncovering crystal growth and regeneration mechanism to control crystal morphology: The case study of aceclofenac

Jiang, Longping; Chen, Wenqian; Zhou, Limin; Xu, Li; He, Feiqiang; Heng, Jerry Y.Y.; Shehzad, Hamza; Ouyang, Jinbo

doi:10.1016/j.seppur.2024.127577

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…Considering the non-negligible role of solvents in the regulation of crystal morphology, it is of great significance to choose the appropriate solvent system to produce APIs with desirable crystal habits. Jiang et al [89] conducted a crystal regrowth experiment in methyl acetate and found that the broken aceclofenac crystal could be restored to its original form, as shown in Figure 7. Compared with the crystal obtained in acetone, it was found that the aceclofenac crystal in methyl acetate had a larger aspect ratio.…”

Section: Solventsmentioning

confidence: 99%

Crystal Morphology Prediction Models and Regulating Methods

Gao,

Song,

Yang

et al. 2024

Crystals

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Growing high-quality crystals with ideal properties is of great importance. The morphology of crystal is one key factor reflecting product quality, as it can affect the performance of products and downstream operations. In this work, the current state of crystal morphology modification is reviewed from different perspectives. First, the most widely used crystal growth models are discussed. Then, a variety of crystal morphology control methods, which include adjustment of crystallization operation parameters, addition of foreign molecules, change of different solvents, membrane assistance, the addition of external physical fields and the use of ball milling are summarized. As for applications, the control of crystal morphology has application potential in pharmaceutical and material fields, for example, energetic materials and semiconductor materials. Finally, the future development direction of crystal morphology regulation is discussed.

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Section: Solventsmentioning

confidence: 99%