Uncovering distinct progression patterns of tau deposition in progressive supranuclear palsy using [18F]Florzolotau PET imaging and subtype/stage inference algorithm

Hong, Jimin; Lu, Jiaying; Liu, Fengtao; Wang, Min; Li, Xinyi; Clement, Christoph; Lopes, Leonor; Brendel, Matthias; Rominger, Axel; Yen, Tzu-Chen; Guan, Yihui; Tian, Mei; Wang, Jian; Zuo, Chuantao; Shi, Kuangyu; Wang, Jian; Liu, Fengtao; Zuo, Chuantao; Wu, Jianjun; Sun, Yimin; Wu, Ping; Tang, Yilin; Zhao, Jue; Wu, Bin; Shen, Bo; Lu, Jiaying; Zhou, Xinyue; Li, Xinyi; Zhang, Huiwei; Ge, Jingjie; Chen, Minjia; Ju, Zizhao

doi:10.1016/j.ebiom.2023.104835

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…8 In addition, a recent study using tau PET identified 2 distinct progression patterns of tau trajectories in PSP. 9 The glymphatic system is a waste clearance system, and glymphatic dysfunction has been proposed as a final common pathway for the accumulation of pathological proteins leading to clinical symptoms in primary neurodegenerative diseases. 10 Several studies have demonstrated impairment of the human glymphatic system in subcortical diseases, such as PSP, Parkinson disease (PD), and corticobasal syndrome.…”

Section: Background Tauopathy In Progressive Supranuclear Palsymentioning

confidence: 99%

“…Two distinct spatiotemporal patterns with associated clinical features in PSP have been identified in another study using tau PET imaging. 9 They found that tau spread appeared first in the subcortical regions and ultimately in the cortical regions. In our study, the subcortical tau burden demonstrated a significant difference between patients with PSP and NCs.…”

Section: Cortical and Subcortical Tau Burden Contributes To Different...mentioning

confidence: 99%

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Dominance of Tau Burden in Cortical Over Subcortical Regions Mediates Glymphatic Activity and Clinical Severity in PSP

Hsu,

Wei,

Hsiao

et al. 2024

Clin Nucl Med

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Background Progressive supranuclear palsy (PSP) is a tauopathy that involves subcortical regions but also extends to cortical areas. The clinical impact of different tau protein sites and their influence on glymphatic dysfunction have not been investigated. Patients and Methods Participants (n = 55; 65.6 ± 7.1 years; 29 women) with PSP (n = 32) and age-matched normal controls (NCs; n = 23) underwent 18F-Florzolotau tau PET, MRI, PSP Rating Scale (PSPRS), and Mini-Mental State Examination. Cerebellar gray matter (GM) and parametric estimation of reference signal intensity were used as references for tau burden measured by SUV ratios. Glymphatic activity was measured by diffusion tensor image analysis along the perivascular space (DTI-ALPS). Results Parametric estimation of reference signal intensity is a better reference than cerebellar GM to distinguish tau burden between PSP and NCs. PSP patients showed higher cortical and subcortical tau SUV ratios than NCs (P < 0.001 and <0.001). Cortical and subcortical tau deposition correlated with PSPRS, UPDRS, and Mini-Mental State Examination scores (all P’s < 0.05). Cortical tau deposition was further associated with the DTI-ALPS index and frontal-temporal-parietal GM atrophy. The DTI-ALPS indexes showed a significantly negative correlation with the PSPRS total scores (P < 0.01). Finally, parietal and occipital lobe tau depositions showed mediating effects between the DTI-ALPS index and PSPRS score. Conclusions Cortical tau deposition is associated with glymphatic dysfunction and plays a role in mediating glymphatic dysfunction and clinical severity. Our results provide a possible explanation for the worsening of clinical severity in patients with PSP.

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Section: Background Tauopathy In Progressive Supranuclear Palsymentioning

confidence: 99%

Section: Cortical and Subcortical Tau Burden Contributes To Different...mentioning

confidence: 99%

Dominance of Tau Burden in Cortical Over Subcortical Regions Mediates Glymphatic Activity and Clinical Severity in PSP

Hsu,

Wei,

Hsiao

et al. 2024

Clin Nucl Med

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View full text Add to dashboard Cite

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Identification of metabolic progression and subtypes in progressive supranuclear palsy by PET molecular imaging

Wang,

Liao

et al. 2024

Eur J Nucl Med Mol Imaging

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Uncovering distinct progression patterns of tau deposition in progressive supranuclear palsy using [18F]Florzolotau PET imaging and subtype/stage inference algorithm

Cited by 2 publications

References 41 publications

Dominance of Tau Burden in Cortical Over Subcortical Regions Mediates Glymphatic Activity and Clinical Severity in PSP

Dominance of Tau Burden in Cortical Over Subcortical Regions Mediates Glymphatic Activity and Clinical Severity in PSP

Identification of metabolic progression and subtypes in progressive supranuclear palsy by PET molecular imaging

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