2023
DOI: 10.3389/fphar.2023.1171512
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Uncovering key molecules and immune landscape in cholestatic liver injury: implications for pathogenesis and drug therapy

Abstract: Background: Cholestasis is a common pathological process in a variety of liver diseases that may lead to liver fibrosis, cirrhosis, and even liver failure. Cholestasis relief has been regarded as a principal target in the management of multiple chronic cholestasis liver diseases like primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) at present. However, complicated pathogenesis and limited acknowledgments fettered therapeutic development. Therefore, this study aimed to systematically a… Show more

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