Uncovering Modern Clinical Applications of Fuzi and Fuzi-Based Formulas: A Nationwide Descriptive Study With Market Basket Analysis

Tai, Chi-Jung; El-Shazly, Mohamed; Tsai, Yi‐Hong; Csupor, Dezső; Hohmann, Judit; Wu, Yang‐Chang; Tseng, Tzyy-Guey; Chang, Fang‐Rong; Wang, Hui‐Chun

doi:10.3389/fphar.2021.641530

Cited by 20 publications

(13 citation statements)

References 23 publications

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“…Fuzi uses in reasonable doses and time has been shown to be of clinical value in saving dying lives in Chinese history. 37 However, although several published studies have shown that the aqueous extract of Fuzi is involved in the generation and removal of oxygen radicals and reduced apoptosis in Wistar rats and SH-SY5Y cells, respectively, 7 why Fuzi is related to the therapeutic effects of vascular aging diseases is still unknown, especially which compound of Fuzi plays a crucial role in vascular aging has not been reported. Moreover, due to the complex chemical components, it remains challenging to elucidate the precise pharmacological mechanisms of Fuzi in treating VS.…”

Section: Discussionmentioning

confidence: 99%

Discovery of deoxyandrographolide and its novel effect on vascular senescence by targeting HDAC1

Lin,

He,

Xian

et al. 2023

MedComm

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Aconitum carmichaelii (Fuzi) is a traditional Chinese medicine that has been widely used in the clinic to save the dying life for over several thousand years. However, the medicinal components of Fuzi in treating vascular senescence (VS) and its potential mechanism remain unclear. In this study, a network pharmacology method was used to explore the possible components and further validated by experiments to get a candidate compound, deoxyandrographolide (DA). DA restrains aging biomarkers, such as p16, p21, γH2A.X, and p53 in vitro and in vivo blood co‐culture studies. Histone deacetylase 1 (HDAC1), mouse double minute2 (MDM2), cyclin‐dependent kinase 4, and mechanistic target of rapamycin kinase (mTOR) are predicted to be the possible targets of DA based on virtual screening. Subsequent bio‐layer interferometry results indicated that DA showed good affinity capability with HDAC1. DA enhances the protein expression of HDAC1 in the angiotensin II‐induced senescence process by inhibiting its ubiquitination degradation. Loss of HDAC1 by CRISPR/Cas9 leads to the disappearance of DA's anti‐aging property. The enhancement of HDAC1 represses H3K4me3 (a biomarker of chromosomal activity) and improves chromosome stability. RNA sequencing results also confirmed our hypothesis. Our evidence illuminated that DA may achieve as a novel compound in the treatment of VS by improving chromosome stability.

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Section: Discussionmentioning

confidence: 99%

Discovery of deoxyandrographolide and its novel effect on vascular senescence by targeting HDAC1

Lin,

He,

Xian

et al. 2023

MedComm

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“…Likewise, in the combination of Fuzi and Astragali radix, astragalus polysaccharide can not only enhance the function of the immune system, but also prevent and treat atherosclerosis, and enhance the therapeutic effect of Fuzi. In addition, through the exploration of Tai et al (2021) , some innovative herbal pairs were found, such as the effect of Fuzi and Ziziphi spinosae semen combination in the treatment of neurological diseases, the effect of Salviae miltiorrhizae radix et rhizoma and Fuzi combination in the treatment of cardiovascular diseases, and the effect of Fuzi in the treatment of cardiovascular diseases was enhanced by Corydalis rhizoma, Cyathulae radix, and Eucommiae cortex. The discovery of these herbal pairs suggests that Fuzi has a broader application, and it is necessary to further explore the specific mechanism of its action.…”

Section: Clinical Application Of Fuzi On Cardiotonic Effectmentioning

confidence: 99%

Processed lateral root of Aconitum carmichaelii Debx.: A review of cardiotonic effects and cardiotoxicity on molecular mechanisms

Zhang

Zhong

et al. 2022

Front. Pharmacol.

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Fuzi, the lateral root of A. carmichaelii Debx., is a typical traditional herbal medicine with both poisonousness and effectiveness, and often used in the treatment of heart failure and other heart diseases. In this review, we searched domestic and foreign literature to sort out the molecular mechanisms of cardiotonic and cardiotoxicity of Fuzi, also including its components. The major bioactive components of Fuzi for cardiotonic are total alkaloids, polysaccharide and the water-soluble alkaloids, with specific mechanisms manifested in the inhibition of myocardial fibrosis, apoptosis and autophagy, and improvement of mitochondrial energy metabolism, which involves RAAS system, PI3K/AKT, JAK/STAT, AMPK/mTOR signaling pathway, etc. Diester-diterpenoid alkaloids in Fuzi can produce cardiotoxic effects by over-activating Na+ and Ca2+ ion channels, over-activating NLRP3/ASC/caspase-3 inflammatory pathway and mitochondria mediated apoptosis pathway. And three clinically used preparations containing Fuzi are also used as representatives to summarize their cardiac-strengthening molecular mechanisms. To sum up, Fuzi has shown valuable cardiotonic effects due to extensive basic and clinical studies, but its cardiotonic mechanisms have not been systematically sorted out. Therefore, it is a need for deeper investigation in the mechanisms of water-soluble alkaloids with low content but obvious therapeutic effect, as well as polysaccharide.

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“…In this study, association rules mining is used to discover association relationships in transactional databases, and there are different application scenarios, such as Chinese medicine prescription data ( 23 ) and disease clinical symptom data ( 24 ). Similarly, there are wide applications in the field of bioinformatics ( 25 ), such as probing gene expression patterns in specific cells ( 26 ), identifying associated genes in gene expression and methylation data ( 27 ), and cancer co-expression gene module detection ( 28 ).…”

Section: Introductionmentioning

confidence: 99%

Synergistic horizontal transfer of antibiotic resistance genes and transposons in the infant gut microbial genome

Ding,

Jiang,

et al. 2024

mSphere

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Transposons, plasmids, bacteriophages, and other mobile genetic elements facilitate horizontal gene transfer in the gut microbiota, allowing some pathogenic bacteria to acquire antibiotic resistance genes (ARGs). Currently, the relationship between specific ARGs and specific transposons in the comprehensive infant gut microbiome has not been elucidated. In this study, ARGs and transposons were annotated from the Unified Human Gastrointestinal Genome (UHGG) and the Early-Life Gut Genomes (ELGG). Association rules mining was used to explore the association between specific ARGs and specific transposons in UHGG, and the robustness of the association rules was validated using the external database in ELGG. Our results suggested that ARGs and transposons were more likely to be relevant in infant gut microbiota compared to adult gut microbiota, and nine robust association rules were identified, among which Klebsiella pneumoniae , Enterobacter hormaechei_A , and Escherichia coli_D played important roles in this association phenomenon. The emphasis of this study is to investigate the synergistic transfer of specific ARGs and specific transposons in the infant gut microbiota, which can contribute to the study of microbial pathogenesis and the ARG dissemination dynamics. IMPORTANCE The transfer of transposons carrying antibiotic resistance genes (ARGs) among microorganisms accelerates antibiotic resistance dissemination among infant gut microbiota. Nonetheless, it is unclear what the relationship between specific ARGs and specific transposons within the infant gut microbiota. K. pneumoniae , E. hormaechei_A , and E. coli_D were identified as key players in the nine robust association rules we discovered. Meanwhile, we found that infant gut microorganisms were more susceptible to horizontal gene transfer events about specific ARGs and specific transposons than adult gut microorganisms. These discoveries could enhance the understanding of microbial pathogenesis and the ARG dissemination dynamics within the infant gut microbiota.

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Uncovering Modern Clinical Applications of Fuzi and Fuzi-Based Formulas: A Nationwide Descriptive Study With Market Basket Analysis

Cited by 20 publications

References 23 publications

Discovery of deoxyandrographolide and its novel effect on vascular senescence by targeting HDAC1

Discovery of deoxyandrographolide and its novel effect on vascular senescence by targeting HDAC1

Processed lateral root of Aconitum carmichaelii Debx.: A review of cardiotonic effects and cardiotoxicity on molecular mechanisms

Synergistic horizontal transfer of antibiotic resistance genes and transposons in the infant gut microbial genome

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