Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight

Abstract

Polydatin or 3-O-β-d-resveratrol-glucopyranoside (PD), a stilbenoid component of Polygonum cuspicadum (Polygonaceae), has a variety of biological roles. In traditional Chinese medicine, P. cuspicadum extracts are used for the treatment of infections, inflammation, and cardiovascular disorders. Polydatin possesses a broad range of biological activities including antioxidant, anti-inflammatory, anticancer, and hepatoprotective, neuroprotective, and immunostimulatory effects. Currently, a major proportion of the population is victimized with cervical lung cancer, ovarian cancer and breast cancer. PD has been recognized as a potent anticancer agent. PD could effectively inhibit the migration and proliferation of ovarian cancer cells, as well as the expression of the PI3K protein. The malignancy of lung cancer cells was reduced after PD treatments via targeting caspase 3, arresting cancer cells at the S phase and inhibiting NLRP3 inflammasome by downregulation of the NF-κB pathway. This ceases cell cycle, inhibits VEGF, and counteracts ROS in breast cancer. It also prevents cervical cancer by regulating epithelial-to-mesenchymal transition (EMT), apoptosis, and the C-Myc gene. The objective of this review is thus to unveil the polydatin anticancer potential for the treatment of various tumors, as well as to examine the mechanisms of action of this compound.

Polydatin and Nicotinamide Rescue the Cellular Phenotype of Mitochondrial Diseases by Mitochondrial Unfolded Protein Response (mtUPR) Activation

“…On the other hand, polydatin, a resveratrol glucoside, has been used for the treatment of various diseases due to its versatile properties, including anti-inflammatory, hypoglycemic, antipyretic, diuretic, expectorant, hypolipidemic, hypouricemic, anticarcinogenic, antioxidant, and anti-atherosclerotic effects [128][129][130][131][132]. Its antioxidant capability is based on the activation of Nrf2, the most important transcription factor against oxidative stress that is also involved in mtUPR [133].…”

Natural resveratrol analogs differentially target endometriotic cells into apoptosis pathways

“…Polydatin represents a natural precursor of resveratrol, in which the hydroxyl is replaced and occupied by a glucopyranoside ring, enabling much better bioavailability than resveratrol, benefiting from the way entering cells via glucose carriers 50 . A number of studies have suggested that polydatin therapeutic effect originates from its anti-inflammatory 51 , antioxidant 52 , and anticancer 53 activities. It remains unclear whether polydatin, like resveratrol, has antioxidation and antitumor properties or constitutes a clinically advantageous approach.…”

Multi-Anticancer Activities of Phytoestrogens in Human Osteosarcoma

“…Furthermore, comparative studies of polydatin and resveratrol regarding antioxidative effects in vivo have revealed a better antioxidant activity of polydatin than resveratrol [312,320]. Polydatin has been recognized as a potent anticancer agent, with the ability to regulate various signaling pathways involved in the progression of several kinds of cancers [321,322]. It is mainly involved in cell cycle regulation, apoptosis, autophagy, signaling pathways, EMT, inhibition of inflammation and metastasis, and regulation of enzymes related to oxidative stress [323,324].…”