Uncovering the Impact of Lymphadenectomy in Advanced Gastric Cancer: A Comprehensive Review

Dinescu, Venera-Cristina; Gheorman, Veronica; Georgescu, Eugen Florin; Paitici, Ștefan; Bică, Marius; Pătrașcu, Ștefan; Bunescu, Marius Gabriel; Popa, Romeo; Berceanu, Mihaela Corina; Pătrașcu, Ana Maria; Gheorman, Lavinia Maria; Dinescu, Sorin Nicolae; Udriștoiu, Ion; Gheorman, Victor; Forțofoiu, Mircea Cătălin; Cojan, Tiberiu-Ștefăniță Țenea

doi:10.3390/life13081769

Cited by 3 publications

(1 citation statement)

References 66 publications

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“…Gastric cancer is one of the most common gastrointestinal malignancies, and postoperative recurrence and metastases were the leading cause of death among patients [1,2] . In order to assess the possibility of postoperative recurrence and metastasis more accurately and comprehensively, it is necessary to search for more effective indicators.…”

Section: Introductionmentioning

confidence: 99%

Values of Serum CEA, CA199, CA72-4 and CA125 Levels in Evaluating Lymph Node Metastases in Gastric Cancer

Nie,

Li,

et al. 2023

Preprint

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This study aimed to investigate the association between the serum levels of carbohydrate antigen 199 (CA199), carbohydrate antigen 72 − 4 (CA72-4), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA) and lymph node metastases in patients with gastric cancer. 200 gastric cancer patients from the First Affiliated Hospital of Hebei North University were selected to determine the concentrations of serum CEA, CA19-9, CA72-4 and CA125. The levels of serum CEA, CA19-9, CA72-4 and CA125 increased with the number of lymph node metastases. The results showed statistically significant differences in the levels of CEA, CA199 and CA72-4 among groups of N0, N1, N2 and N3 (p < 0.05). No significant difference was observed in the CA125 level among the groups of N0, N1 and N2 (p > 0.05), while the level of CA125 in group N3 was significantly higher than that in the other groups (p < 0.05). Comparing to the N0 group, the positive rates of four tumor markers in the N1 + N2 + N3 group were significantly increased in both single-marker detection and combined detection (p < 0.05). In the N1 + N2 + N3 group, the positive rates of combined detection of two, three and four tumor markers were significantly higher than that of the single-marker detection (p < 0.05). The results of combined detection showed no statistically significant difference between the groups that included CA125 and the groups that only contained other tumor markers (p > 0.05). Combined detection of CEA, CA19-9, CA72-4 and CA125 tumor markers may be of great significance in determining lymph node metastases in gastric cancer. CEA, CA19-9 and CA72-4 may have higher clinical value compared to CA125.

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Section: Introductionmentioning

confidence: 99%

Values of Serum CEA, CA199, CA72-4 and CA125 Levels in Evaluating Lymph Node Metastases in Gastric Cancer

Nie,

Li,

et al. 2023

Preprint

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Risk factors for pneumonia after radical gastrectomy for gastric cancer: A systematic review and meta-analysis

Fan,

Jiang,

et al. 2024

Preprint

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Objective The objective is to systematically gather the relevant research to determine and quantify the risk factors for pneumonia after a radical gastrectomy for gastric cancer. Methods The reporting procedures of this meta-analysis conformed to the PRISMA 2020. Chinese Wan Fang data, Chinese National Knowledge Infrastructure (CNKI), Chinese Periodical Full-text Database (VIP), Embase, Scopus, CINAHL, Ovid MEDLINE, PubMed, Web of Science, Cochrane Library, Embase, and Scopus from the time of inception to January 20, 2024, data were systematically searched for cohort or case-control studies that reported particular risk factors for pneumonia after radical gastrectomy for gastric cancer. The quality was assessed using the Newcastle-Ottawa Scale after the chosen studies had been screened and the data retrieved. Rev Man 5.4 was the program used to perform the meta-analysis. Results Our study included data from 27,840 individuals across 27 trials. Fifteen risk factors were statistically significant, according to pooled analyses. Several factors were identified to be strong risk factors (OR: 2.21–4.72), including smoking history, prolonged postoperative nasogastric tube retention, intraoperative bleeding ≥ 200 ml, diabetes mellitus, male gender, total gastrectomy, COPD, impaired respiratory function, D2 lymphadenectomy, perioperative blood transfusion, and hypertension. Moderate risk factors included excessive surgery duration, advanced age, nutritional status, and history of pulmonary disease (OR: 1.51–1.91). Conclusions The study identified 15 independent risk factors significantly associated with pneumonia after radical gastrectomy for gastric cancer. These results offer evidence-based procedures for putting into practice successful preventive interventions.

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A Comprehensive Review on Comparative Analysis of Operative Efficiency and Postoperative Recovery in Robotic Versus Laparoscopic Hepatectomy

Khan,

Mahakalkar,

Kshirsagar

et al. 2024

Cureus

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Minimally invasive liver surgery, particularly hepatectomy, has evolved significantly with the advent of laparoscopic and robotic techniques. These approaches offer potential benefits over traditional open surgery, including reduced postoperative pain, shorter hospital stays, faster recovery, and improved cosmetic outcomes. This comprehensive review aims to compare the operative efficiency and postoperative recovery outcomes of robotic and laparoscopic hepatectomy. It seeks to provide an in-depth analysis of the advantages and limitations of each technique, assess their cost-effectiveness, and explore emerging trends and future directions in minimally invasive liver surgery. A comprehensive literature search was conducted to identify studies comparing robotic and laparoscopic hepatectomy. The review includes an analysis of operative time, intraoperative blood loss, conversion rates, postoperative pain, length of hospital stay, complication rates, oncological outcomes, and overall cost. Additionally, advancements in technology and future research directions were explored to provide a comprehensive overview of the current landscape and future potential of these surgical techniques. Both robotic and laparoscopic hepatectomy have demonstrated comparable outcomes in terms of oncological safety and effectiveness. However, robotic hepatectomy offers advantages in terms of precision and dexterity, particularly in complex cases, due to its advanced visualization and instrumentation. Laparoscopic hepatectomy, while associated with shorter operative times and lower costs, is limited by technical challenges, especially in major liver resections. The review also highlights the increasing adoption of robotic systems, despite their higher costs and the need for specialized training. Robotic and laparoscopic hepatectomy are both viable options for minimally invasive liver surgery, each with distinct advantages and limitations. The choice between the two should be based on patient-specific factors, the complexity of the procedure, and the surgeon's expertise. Ongoing advancements in technology, including the integration of artificial intelligence and augmented reality, are expected to further refine these techniques, enhancing their efficacy and accessibility. Future research should focus on large-scale, multicenter trials to provide more definitive comparisons and guide clinical decision-making.

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Uncovering the Impact of Lymphadenectomy in Advanced Gastric Cancer: A Comprehensive Review

Cited by 3 publications

References 66 publications

Values of Serum CEA, CA199, CA72-4 and CA125 Levels in Evaluating Lymph Node Metastases in Gastric Cancer

Values of Serum CEA, CA199, CA72-4 and CA125 Levels in Evaluating Lymph Node Metastases in Gastric Cancer

Risk factors for pneumonia after radical gastrectomy for gastric cancer: A systematic review and meta-analysis

A Comprehensive Review on Comparative Analysis of Operative Efficiency and Postoperative Recovery in Robotic Versus Laparoscopic Hepatectomy

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