Uncovering the Importance of Selenium in Muscle Disease

Abstract

A connection between selenium bioavailability and development of muscular disorders both in humans and livestock has been established for a long time. With the development of genomics, the function of several selenoproteins was shown to be involved in muscle activity, including SELENON, which was linked to an inherited form of myopathy. Development of animal models has helped to dissect the physiological dysfunction due to mutation in the SELENON gene; however the molecular activity remains elusive and only recent analysis using both in vivo and in vitro experiment provided hints toward its function in oxidative stress defence and calcium transport control. This review sets out to summarise most recent findings for the importance of selenium in muscle function and the contribution of this information to the design of strategies to cure the diseases.

Biogenic Selenium Nanoparticles for Their Therapeutic Application

“…At the present time, different microorganisms, such as bacteria, yeast, fungi, and some biofriendly agents, have been considered as eco-friendly green biofactories for the fabrication of Se nanomaterials. Sodium selenite is used to control selenium deficiency called nutritional muscular dystrophy or white muscle disease [24]. In ruminants, selenium supplements are transformed partiality in…”