Uncovering the mechanism of quercetin for treating spermatogenesis impairment by a network pharmacology approach

Liu, Sijia; Hu, Su-Qin; Chen, Yu-Cai; Guo, Jian

doi:10.1080/26895293.2021.1961878

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2024

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Cited by 3 publications

References 57 publications

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Gut aging: A wane from the normal to repercussion and gerotherapeutic strategies

Abankwah,

Wang,

Wang

et al. 2024

Heliyon

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Gut aging: A wane from the normal to repercussion and gerotherapeutic strategies

Abankwah,

Wang,

Wang

et al. 2024

Heliyon

View full text Add to dashboard Cite

Gut Aging: A Wane from the Normal to Repercussion and Gerotherapeutic Strategies

Abankwah,

Wang,

Wang

et al. 2024

Preprint

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Assessing the Efficacy of Acanthoic Acid Isolated from Acanthopanax koreanum Nakai in Male Infertility: An In Vivo and In Silico Approach

Phong,

Kim,

Park

et al. 2024

CIMB

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Acanthoic acid, a diterpene isolated from the root bark of Acanthopanax koreanum Nakai, possesses diverse pharmacological activities, including anti-inflammatory, anti-diabetic, gastrointestinal protection, and cardiovascular protection. This study is the first to investigate the egg-hatching rates of Drosophila melanogaster affected by acanthoic acid. Notably, male flies supplemented with 10 μM acanthoic acid exhibited a strong increase in hatching rates compared with controls under adverse temperature conditions, suggesting a potential protective effect against environmental stressors. Molecular docking simulations revealed the binding affinities and specific interactions between acanthoic acid and proteins related to male infertility, including SHBG, ADAM17, and DNase I, with binding affinity values of −10.2, −6.8, and −5.8 kcal/mol, respectively. Following the docking studies, molecular dynamic simulations were conducted for a duration of 100 ns to examine the stability of these interactions. Additionally, a total binding energy analysis and decomposition analysis offered insights into the underlying energetic components and identified key contributing residues.

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Uncovering the mechanism of quercetin for treating spermatogenesis impairment by a network pharmacology approach

Cited by 3 publications

References 57 publications

Gut aging: A wane from the normal to repercussion and gerotherapeutic strategies

Gut aging: A wane from the normal to repercussion and gerotherapeutic strategies

Gut Aging: A Wane from the Normal to Repercussion and Gerotherapeutic Strategies

Assessing the Efficacy of Acanthoic Acid Isolated from Acanthopanax koreanum Nakai in Male Infertility: An In Vivo and In Silico Approach

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