Uncultivated stromal vascular fraction is equivalent to adipose‐derived stem and stromal cells on porous polyurethrane scaffolds forming adipose tissue in vivo

Griessl, Michael; Buchberger, Anna-Maria; Regn, Sybille; Kreutzer, Kilian; Storck, Katharina

doi:10.1002/lary.27124

Cited by 2 publications

(1 citation statement)

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“…This concept has been successfully demonstrated in applications such as siloxane maxillofacial implants, polyurethane cardiovascular occlusive devices, and collagen-derived adipose tissue scaffolds [5][6][7][8][9][10][11] . However, current porous materials leveraged for these applications are limited by their pore morphological distribution, in addition to other issues such as post-processing requirements prior to use [5][6][7][9][10][11][12][13][14][15][16][17][18][19][20][21] . 3D printing has emerged as one of the most promising methods to overcome these processing limitations as a consequence of the reproducible, interconnected pore features with micronscale resolution that can be manufactured in precise designs.…”

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confidence: 99%

4D polycarbonates via stereolithography as scaffolds for soft tissue repair

Weems

Arno

et al. 2021

Nat Commun

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Abstract3D printing has emerged as one of the most promising tools to overcome the processing and morphological limitations of traditional tissue engineering scaffold design. However, there is a need for improved minimally invasive, void-filling materials to provide mechanical support, biocompatibility, and surface erosion characteristics to ensure consistent tissue support during the healing process. Herein, soft, elastomeric aliphatic polycarbonate-based materials were designed to undergo photopolymerization into supportive soft tissue engineering scaffolds. The 4D nature of the printed scaffolds is manifested in their shape memory properties, which allows them to fill model soft tissue voids without deforming the surrounding material. In vivo, adipocyte lobules were found to infiltrate the surface-eroding scaffold within 2 months, and neovascularization was observed over the same time. Notably, reduced collagen capsule thickness indicates that these scaffolds are highly promising for adipose tissue engineering and repair.

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