Under arrest: cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs

Tunquist, Brian; Maller, James L.

doi:10.1101/gad.1071303

Cited by 229 publications

(194 citation statements)

References 301 publications

(357 reference statements)

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“…A spindle migration defect is long known for the c-Mos mutant mouse oocytes [Choi et al, 1996]. As an activator of the MAPK cascade, c-Mos is crucial for meiosis resumption and for the maintenance of MII arrest in vertebrate oocytes [Kosako et al, 1994a,b;Tunquist and Maller, 2003]. c-Mos null oocytes fail to undergo spindle migration, which results in production of a large polar body during cell division.…”

Section: Spindle Migration: Where and How The Force Is Generatedmentioning

confidence: 99%

Actin cytoskeleton in cell polarity and asymmetric division during mouse oocyte maturation

2012

Cytoskeleton

104

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Mammalian oocyte maturation involves two successive rounds of extremely asymmetric cell divisions (known as polar body extrusion) to generate a functional haploid egg. Successful polar body extrusion relies on establishment of an asymmetric spindle position and cortical polarity. Decades of studies using mouse oocytes as a model have revealed critical roles for a dynamic actin cytoskeleton in this process. Here, we review the contribution of actin to the critical events during oocyte meiotic cell divisions with an emphasis on recent advances in understanding the underlying molecular and physical mechanisms. V C 2012 Wiley Periodicals, Inc

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Section: Spindle Migration: Where and How The Force Is Generatedmentioning

confidence: 99%

Actin cytoskeleton in cell polarity and asymmetric division during mouse oocyte maturation

2012

Cytoskeleton

104

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“…In Xenopus and mouse, exit from meiosis requires ubiquitin-mediated degradation of many proteins including cyclins and securin (reviewed in Tunquist and Maller, 2003). In C. elegans, protein degradation is necessary for the meiosis-to-mitosis transition and the establishment of polarity.…”

Section: Maternal Protein Degradation and Phosphorylationmentioning

confidence: 99%

Transitioning from egg to embryo: Triggers and mechanisms of egg activation

Horner

Wolfner

2008

Developmental Dynamics

183

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The transition from mature oocyte to developing embryo requires a coordinated series of events, collectively known as egg activation. Egg activation includes changes to egg coverings to prevent polyspermy, release of oocyte meiotic arrest, generation of haploid female and male pronuclei, changes in maternal mRNAs and protein populations, and cytoskeletal rearrangements. In many animals, egg activation is triggered by fertilization, which increases intracellular calcium within the oocyte and thereby regulates molecular events of egg activation. In other animals, fertilization-independent external signals, including mechanical stimulation of eggs and/or changes in ionic milieu, trigger activation. Recent studies have clarified the upstream portion of pathways leading to eggshell changes and cell cycle resumption and have identified activation-induced changes in maternal mRNA and protein profiles that can identify molecular players in the downstream events of egg activation. We review signals that trigger activation and how they link to subsequent molecular events of egg activation. Developmental Dynamics 237:527-544, 2008.

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“…This includes germinal vesicle breakdown (GVBD), chromosome condensation, completion of meiosis I coupled with the extrusion of a polar body, followed by arrest at metaphase of meiosis II (Smith, 1989;Bement and Capco, 1990). MII arrest is maintained by an activity referred to as cytostatic factor (CSF), which inhibits the anaphase promoting complex (APC) (Tunquist and Maller, 2003). APC is a ubiquitin ligase that targets cyclins and other regulatory proteins for degradation leading to a decrease in MPF activity and progression to anaphase.…”

Section: Oocyte Maturationmentioning

confidence: 99%

Ca²⁺ signaling differentiation during oocyte maturation

Machaca

2007

Journal Cellular Physiology

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Oocyte maturation is an essential cellular differentiation pathway that prepares the egg for activation at fertilization leading to the initiation of embryogenesis. An integral attribute of oocyte maturation is the remodeling of Ca 2þ signaling pathways endowing the egg with the capacity to produce a specialized Ca 2þ transient at fertilization that is necessary and sufficient for egg activation. Consequently, mechanistic elucidation of Ca 2þ signaling differentiation during oocyte maturation is fundamental to our understanding of egg activation, and offers a glimpse into Ca 2þ signaling regulation during the cell cycle.

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Under arrest: cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs

Cited by 229 publications

References 301 publications

Actin cytoskeleton in cell polarity and asymmetric division during mouse oocyte maturation

Actin cytoskeleton in cell polarity and asymmetric division during mouse oocyte maturation

Transitioning from egg to embryo: Triggers and mechanisms of egg activation

Ca²⁺ signaling differentiation during oocyte maturation

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Under arrest: cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs

Cited by 229 publications

References 301 publications

Actin cytoskeleton in cell polarity and asymmetric division during mouse oocyte maturation

Actin cytoskeleton in cell polarity and asymmetric division during mouse oocyte maturation

Transitioning from egg to embryo: Triggers and mechanisms of egg activation

Ca2+ signaling differentiation during oocyte maturation

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Ca²⁺ signaling differentiation during oocyte maturation