Under-recognized toxicities of cranial irradiation

Guyader, M. Le; Antoni, D.

doi:10.1016/j.canrad.2021.06.019

Cited by 4 publications

(1 citation statement)

References 88 publications

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“…For many cancer patients, CT is the primary form of treatment, and its short- and long-term effect on chemosensory alterations is less understood. Radiotherapy is a well-known cause of chemosensory dysfunction, as it can lead to direct damage of taste receptors, synaptic uncoupling, and other neurological damage [ 59 , 60 ]. RT (especially in head and neck cancer) can also cause hypo-salivation and dry mouth, resulting in reduced delivery of chemical stimulants to receptors, resulting in a prevalence of 50% of smell and 70% of taste alterations [ 61 , 62 ].…”

Section: Resultsmentioning

confidence: 99%

Taste and Smell Alterations (TSAs) in Cancer Patients

Rosati,

Mastino,

Romeo

et al. 2024

Diseases

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Recently, smell and taste disorders have seen renewed interest, as these symptoms are frequent complications of SARS-CoV-2 infection, since approximately 60% of patients affected by COVID-19 have shown olfactory and gustatory alterations. Otolaryngology pays attention to taste and smell abnormalities (TSAs), especially when associated with oncology. TSAs are common symptoms in people affected by cancer, yet they are ignored and underestimated. The clinical outcome of TSAs in cancer evidences the importance of identifying them with chemotherapy or radiotherapy in general, and they are associated with many types of cancer. We recognize the findings of the literature on TSAs in cancer, evaluating how it is important to consider and identify these disorders concerning reduced food enjoyment or inappropriate nutrient intake, and modulating the nutritional status, quality of life, and impact of therapy. This review aims to critically evaluate and recognize the assessment and clinical perspectives of taste and smell disorders in a cancer population.

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