Under-representation of women in research: a status quo that is a scandal

Abbasi, Kamran

doi:10.1136/bmj.p2091

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…It is important to note that addressing the underrepresentation of women's health in research has been a longstanding concern. 34 Our data highlights the importance of increasing the inclusion of female donor samples in pre‐clinical research, as well as clinical trials to enhance the comprehensiveness and relevance of findings. Furthermore, elucidating additional sex‐specific mechanisms of regenerative hematopoiesis has also implications for thousands of HSCT transplantations that are performed across the world.…”

Section: Discussionmentioning

confidence: 76%

“…Moving forward, strict adherence to sex‐specific matching protocols will be imperative for the accurate interpretation and advancement of xenotransplantation models, particularly to guide new paths for research into clonal hematopoiesis and hematological disorders. It is important to note that addressing the underrepresentation of women's health in research has been a longstanding concern 34 . Our data highlights the importance of increasing the inclusion of female donor samples in pre‐clinical research, as well as clinical trials to enhance the comprehensiveness and relevance of findings.…”

Section: Discussionmentioning

confidence: 81%

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Influence of donor–recipient sex on engraftment of normal and leukemia stem cells in xenotransplantation

Mian,

Ariza‐McNaughton,

Anjos‐Afonso

et al. 2024

HemaSphere

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Immunodeficient mouse models are widely used for the assessment of human normal and leukemic stem cells. Despite the advancements over the years, reproducibility, as well as the differences in the engraftment of human cells in recipient mice remains to be fully resolved. Here, we used various immunodeficient mouse models to characterize the effect of donor–recipient sex on the engraftment of the human leukemic and healthy cells. Donor human cells and recipient immunodeficient mice demonstrate sex‐specific engraftment levels with significant differences observed in the lineage output of normal CD34+ hematopoietic stem and progenitor cells upon xenotransplantation. Intriguingly, human female donor cells display heightened sensitivity to the recipient mice's gender, influencing their proliferation and resulting in significantly increased engraftment in female recipient mice. Our study underscores the intricate interplay taking place between donor and recipient characteristics, shedding light on important considerations for future studies, particularly in the context of pre‐clinical research.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 81%

Influence of donor–recipient sex on engraftment of normal and leukemia stem cells in xenotransplantation

Mian,

Ariza‐McNaughton,

Anjos‐Afonso

et al. 2024

HemaSphere

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Protecting women heart in Type 2 diabetes mellitus: why, how, and when?

Lainscak,

Margineanu,

Chioncel

et al. 2023

European Journal of Preventive Cardiology

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What are the ethnic inequities in care outcomes related to haematological malignancies, treated with transplant/cellular-therapies, in the UK?

Cusworth,

Deplano,

Denniston

et al. 2024

Preprint

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Introduction Haematological cancers are common in the UK, with a variety of morphologies. Stem cell transplants and chimeric antigen receptor (CAR) T-cell therapies provide significant options for hard to treat haematological cancers, although with difficult to predict outcomes. Research into the determinates of treatment efficacy, and access to treatments, is key to ensuring equal benefit across patients, and patient safety. With this, there are concerns about the small representation of minority groups in related research. We aim to report on the current knowledge, to guide future research. Methods and analysis A variety of databases will be searched, for literature on UK minority ethnic populations receiving haematopoietic stem cell transplant or CAR T-cell therapy. Many outcomes will be analysed, covering the patient care pathway for those of the target population, although with a focus on follow-up after therapy. Plans have been made to conduct narrative synthesis, with meta-analysis where applicable. Ethics and Dissemination Outputs will be published in an appropriate journal, and discussed with the wider NIHR Blood and Transplant Research Unit in Precision Transplant and Cellular Therapeutics (BTRU) group. Discussions will also be undertaken with the BTRU patient partners group. Strengths and Limitations of this Study - This systematic review has a detailed search criteria with a variety of search tools, enabling high sensitivity in obtaining evidence. - To enable this work to be completed, reviewers will be working independently on separate reference lists, during screening, rather than voting on the same references and resolving conflicts. To alleviate issues, reviewers will be first required to screen a defined number of papers together, using a more classical approach to confirm agreement, before working independently. - Due to difficulties in pooling together international ethnic groups, only studies in the UK have been included, to reduce complexity. There are some ethnic groups which are more valid to pool together internationally than others, mainly in respect to genetic factors (as opposed to social), which this protocol does not consider.

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Under-representation of women in research: a status quo that is a scandal

Cited by 7 publications

References 9 publications

Influence of donor–recipient sex on engraftment of normal and leukemia stem cells in xenotransplantation

Influence of donor–recipient sex on engraftment of normal and leukemia stem cells in xenotransplantation

Protecting women heart in Type 2 diabetes mellitus: why, how, and when?

What are the ethnic inequities in care outcomes related to haematological malignancies, treated with transplant/cellular-therapies, in the UK?

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