Underlying and multiple cause mortality in a cohort of workers exposed to aromatic amines

Axtell, Catherine D.; Ward, Elizabeth; McCabe, George P.; Schulte, Paul A.; Stern, Frank; Glickman, Lawrence T.

doi:10.1002/(sici)1097-0274(199811)34:5<506::aid-ajim12>3.0.co;2-5

Cited by 14 publications

(8 citation statements)

References 10 publications

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“…Bladder cancer was not elevated, despite the known excess in incident cases. This con®rms previous observations that studying mortality for cancers that have a high survival rate may lead to spuriously negative ®ndings [Axtell et al, 1998].…”

Section: Discussionsupporting

confidence: 89%

Mortality among rubber chemical manufacturing workers

et al. 2000

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Background A retrospective cohort mortality study evaluated ischemic heart disease (IHD) among workers in the “rubber chemicals” manufacturing department of a Western New York plant. A previous study at the plant found elevated chest pain and angina among workers in this department. Methods Mortality experience of workers employed from 1946–1988 was followed through December 31, 1994. Mortality was compared to U.S. population rates and to local Niagara county rates by using the NIOSH life table analysis system. Poisson regression was used to examine patterns of IHD within the cohort. Results The standardized mortality ratio (SMR) for IHD among workers in the rubber chemicals department was 1.51 (U.S. rates) and 1.19 (Niagara county rates). Increased mortality from IHD in the rubber chemicals department was most pronounced at younger ages (< 50, SMR = 2.4); workers in a second chemical production department also had an elevated (but not statistically significant) SMR of 1.5 for IHD. Conclusions IHD mortality among workers in the rubber chemicals department was elevated, particularly among those under 50 years of age. Potential occupational risk factors for IHD include the rotating shift pattern for employees assigned to two chemical production departments and chemical exposures present in the rubber chemicals department. Am. J. Ind. Med. 37:590–598, 2000. Published 2000 Wiley‐Liss, Inc.

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Section: Discussionsupporting

confidence: 89%

Mortality among rubber chemical manufacturing workers

et al. 2000

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“…Genetic variants of metabolic enzymes are now postulated to result in critical changes in the metabolism of environmental carcinogens and, subsequently, to modify individual bladder cancer susceptibility. Exposure to chemicals, particularly arylamines, through tobacco smoking, fossil fuel emissions, hair dye, and other environmental and occupational sources has been reported as a major risk factor for bladder cancer [9–12]. These suspected carcinogens are normally biotransformed by numerous and complex drug-metabolizing enzymatic pathways.…”

Section: Introductionmentioning

confidence: 99%

N-Acetyltransferase 1 (NAT1) Genotype: A Risk Factor for Urinary Bladder Cancer in a Lebanese Population

Yassine

Kobeissi

Jabbour

et al. 2012

Journal of Oncology

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In Lebanon, bladder cancer is the second most incident cancer among men. This study investigates a possible association between N-acetyltransferase 1 (NAT1) genotype, a drug-metabolizing enzyme coding gene, and bladder cancer in Lebanese men. A case-control study (54 cases and 105 hospital-based controls) was conducted in two major hospitals in Beirut. Cases were randomly selected from patients diagnosed in the period of 2002–2008. Controls were conveniently identified and selected from the same settings. Data was collected using interview questionnaire and blood analysis. NAT1 genotypes were determined by PCR-RFLP. Statistical analysis revolved around univariate, bivariate, and multivariate logistic regression models, along with checks for effect modification. Results showed NAT1∗14A allele, smoking, occupational exposure to combustion fumes, and prostate-related symptoms, to be risk factors for bladder cancer. The odds of carrying at least one NAT1∗14A allele are 7 times higher in cases compared to controls (OR = 7.86, 95% CI: 1.53–40.39). A gene-environment interaction was identified for NAT1∗14A allele with occupational exposure to combustion fumes. Among carriers of NAT1∗14A allele, the odds of bladder cancer dropped to 2.03 from 3.72. Our study suggests NAT1∗14A allele as a possible biomarker for bladder cancer. Further research is recommended to confirm this association.

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“…The workers in all the above studies except those of Wu [1988], andXue-Yun et al [1990] were also exposed to beta-napthylamine, another recognized human carcinogen [IARC Monographs, 1974]. One study of workers exposed to beta-napthylamine but not benzidine found increased esophageal, lung, and prostate cancer [Axtell et al, 1998]. Many other studies of benzidine exposed workers only reported on bladder cancer and provided no data on other types of cancer.…”

Section: Discussionmentioning

confidence: 99%