Underlying mechanisms of carbapenem resistance in extended-spectrum β-lactamase-producing Klebsiella pneumoniae and Escherichia coli isolates at a tertiary care centre in Lebanon: role of OXA-48 and NDM-1 carbapenemases

Molecular Characterization of Carbapenemase-Nonproducing Clinical Isolates of <i>Escherichia coli</i> (from a Thai University Hospital) with Reduced Carbapenem Susceptibility

“…Enzymes CTX-M-15 and CMY-2 were first detected in this hospital in 2003 and 2005, respectively (18,23). These results suggest that CTX-M-15 ESBL is the major β-lactamase responsible for reduced ETP susceptibility among our CNENS E. coli isolates, in line with reports from Hong Kong and Lebanon (4,5). In contrast to this study, CMY-2 expression is mostly associated with Taiwanese CNENS E. coli isolates (8).…”

“…In addition, carbapenemase-negative ETPnonsusceptible (CNENS) clinical isolates of E. coli were detected. Other mechanisms such as decreased drug uptake because of a porin defect or loss, in combination with ESBL or plasmid-mediated AmpC β-lactamase (pAmpC) production or efflux pump overexpression, may be involved in reduced susceptibility or resistance to ETP among our CNENS E. coli isolates as described elsewhere (4)(5)(6)(7)(8). We therefore investigated the molecular resistance mechanisms and relatedness of 12 clinical isolates of CNENS E. coli obtained at a Thai university hospital between 2010 and 2014.…”

One ring to rule them all: Current trends in combating bacterial resistance to the β‐lactams

“…ESBLs include the emerging metallo-b-lactamases (MBLs) such as VIM, NDM, and IMP, and a subset of serine blactamases (SBLs) including KPC, OXA, and GES. 7,8 Perhaps our greatest defense is to match the brilliant diversity of b-lactamases with an evergrowing arsenal of b-lactam/b-lactamase inhibitor combinations. However, due to the omnipresent threat of resistance, the pharmaceutical industry has become increasingly hesitant to develop new antibacterials.…”

Detection Phenotypique Des Carbapenemases Chez Klebsiella Pneumoniae Dans Les Isolats Cliniques Au Maroc.

“…Au Liban, on a effectué une recherche par méthodes phénotypiques et par PCR sur des isolats d'entérobactéries BLSE. 14 Kp / 572 et 24 Escherichia coli/ 2243 étaient résistantes à l'ertapénème et la résistance aux autres carbapénèmes était variable [20]. Dans une étude réalisée en Tunisie, on a isolé 5 souches d'ERC sur les 21 BLSE testées.…”