Undernutrition among Ethiopian adults living with HIV: a meta-analysis

Abstract

Background: Malnutrition and human immunodeficiency virus (HIV) are interlaced in a vicious cycle and worsened in low and middle-income countries. In Ethiopia, even though individuals are dually affected by both malnutrition and HIV, there is no a nationwide study showing the proportion of malnutrition among HIV-positive adults. Consequently, this review addressed the pooled burden of undernutrition among HIV-positive adults in Ethiopia. Methods: We searched for potentially relevant studies through manual and electronic searches. An electronic search was carried out using the database of PubMed, Google Scholar, and Google for gray literature and reference lists of previous studies. A standardized data extraction checklist was used to extract the data from each original study. STATA Version 13 statistical software was used for our analysis. Descriptive summaries were presented in tables, and the quantitative result was presented in a forest plot. Heterogeneity within the included studies was examined using the Cochrane Q test statistics and I 2 test. Finally, a random-effects meta-analysis model was computed to estimate the pooled proportion of undernutrition among HIV-positive adults.

Nutritional status and associated factors among adult on Antiretro-viral therapy in Gamo zone public health facilities, southern Ethiopia

“…The magnitude of underweight in this study is consistent to the study from east Harerge zone (30%) (39), Ethiopia a systematic review and meta-analysis (27.4%) (40), Arba Minch town public health facilities (24%) (41), and Bench Shako zone (29.2%) (42).…”

Association Between Body Mass Index Variation and Early Mortality Among 834 Ethiopian Adults Living with HIV on ART: A Joint Modelling Approach

“…The problem is more prominent in Ethiopia as a result of food insecurity and inadequate knowledge about healthy nutrition [2]. Approximately 26% of adults living with HIV in Ethiopia are undernourished [3] as HIV increases nutritional requirements and reduces food intake because of mouth and throat sores, loss of appetite, medication side effects, and household food insecurity. Furthermore, it decreases nutrient absorption because of HIV infection of intestinal cells, diarrhoea, and vomiting [4].…”

Relation of serum IL-32 levels and gene polymorphism rs45499297 with obesity in Mexican patients: a laboratory and in silico analysis

“…Hepatocyte Nuclear Factor 4 alpha (HNF4α), or its variants, and the transcriptional factor Specificity Protein 1 (SP1) were inferred in different databases. Previous studies reported that the IL32 gene has a binding site for these transcriptional factors (39,40). However, we have inferred that the binding site overlaps with the rs45499297 polymorphism.…”

“…Malnutrition has been associated with HIV and HTLV1 (39,40), so it is inferred that genes co-expressed with IL32 are involved with these metabolic pathways, in addition to the fact that this cytokine is modified in malnourished states. This information is essential to understand disease mechanisms, especially in diseases with a high degree of complexity, such as obesity, in which several metabolic pathways are involved in the pathogenesis of the disease.…”