Undernutrition regulates the expression of a novel splice variant of myostatin and insulin-like growth factor 1 in ovine skeletal muscle

Jeanplong, Ferenc; Osepchook, Claire C.; Falconer, Shelley J.; Smith, Harrison; Bass, J. J.; McMahon, Christopher D.; Oldham, Jenny M.

doi:10.1016/j.domaniend.2015.01.002

Cited by 11 publications

(9 citation statements)

References 54 publications

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“…Our finding that low serum myostatin was an independent risk factor for lower RASM in healthy older adults appears contradictory to current understanding. One explanation may relate to the myostatin splice variant protein, which binds to myostatin and antagonizes canonical signalling; Jeanplong et al reported that an energy‐restricted diet reduced the semitendinosus muscle mass of young ewes and that myostatin activity was inhibited by increased myostatin splice variant expression, implying an important influence of nutritional status on the action of myostatin in skeletal muscle development . Another reason could be differences in the age distributions of study cohorts.…”

Section: Discussionsupporting

confidence: 38%

“…One explanation may relate to the myostatin splice variant protein, which binds to myostatin and antagonizes canonical signalling 25 ; Jeanplong et al reported that an energy-restricted diet reduced the semitendinosus muscle mass of young ewes and that myostatin activity was inhibited by increased myostatin splice variant expression, implying an important influence of nutritional status on the action of myostatin in skeletal muscle development. 25 Another reason could be differences in the age distributions of study cohorts. Yarasheski et al observed that serum myostatin was higher among women aged 76-92 years old than younger ones, 13 indicating that age might influence myostatin expression; however, we found no significant difference in serum myostatin between subjects aged 53-70 vs. ≥70 years.…”

Section: Discussionmentioning

confidence: 99%

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Healthy community‐living older men differ from women in associations between myostatin levels and skeletal muscle mass

Peng

Lee

Liu

et al. 2018

J cachexia sarcopenia muscle

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BackgroundMyostatin is a negative regulator of muscle growth but the relationship between serum myostatin levels and muscle mass is unclear. This study investigated the association between serum myostatin levels and skeletal muscle mass among healthy older community residents in Taiwan, to evaluate the potential of serum myostatin as a biomarker for diagnosing sarcopenia and/or evaluating the effect of its treatment.MethodsStudy data were excerpted from a random subsample of the I‐Lan Longitudinal Aging Study population. Serum myostatin levels were determined and categorized into tertiles (low, medium, high). Relative appendicular skeletal muscle mass (RASM) was calculated as appendicular lean body mass by dual‐energy X‐ray absorptiometry divided by height squared (kg/m2). Low muscle mass was defined as recommended by the Asian Working Group for Sarcopenia.ResultsThe analytic study sample comprised 463 adults (mean age: 69.1 years; 49.5% men). Compared with subjects with normal RASM, those with lower RASM were older and frailer, with significantly higher prevalence of malnutrition, lower serum dehydroepiandrosterone (DHEA) levels, and were more likely to have low serum myostatin status. Multivariable logistic regression analysis showed that male sex (OR 3.60, 95% CI 1.30–9.92), malnutrition (OR 4.39, 95% CI 1.56–12.36), DHEA (OR 0.99, 95% CI 0.99–1.00), and low myostatin (OR 3.23, 95% CI 1.49–7.01) were all independent risk factors for low RASM (all P < 0.05). In men, DHEA (OR 0.99, 95% CI 0.98–1.00) and low myostatin (OR 4.89, 95% CI 1.79–13.37) were significantly associated with low RASM (both P < 0.05); however, only malnutrition was associated with low RASM in women (OR 13.59, 95% CI 2.22–83.25, P < 0.05).ConclusionsAmong healthy community‐living older adults, low serum myostatin levels were associated with low skeletal muscle mass in men, but not in women. Our results do not support using serum myostatin levels to diagnose sarcopenia, or to monitor how it responds to treatments. Further research is needed to understand why men apparently differ from women in the interrelationship between their myostatin levels and muscle mass.

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Section: Discussionsupporting

confidence: 38%

Section: Discussionmentioning

confidence: 99%

Healthy community‐living older men differ from women in associations between myostatin levels and skeletal muscle mass

Peng

Lee

Liu

et al. 2018

J cachexia sarcopenia muscle

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“…In investigations of Jeanplong et al (2015) the expression of the MSTN gene in the muscle tissue of sheep was higher than that of IGF1gene. According to our data, the IGF1 gene was expressed with less intensity than MSTN.…”

Section: Discussionmentioning

confidence: 92%

Genes expression profiles in the loin muscle of Manych Merino sheep with different live weight

Trukhachev¹,

Belyaev²,

Квочко³

et al. 2016

BJVM

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“…Gene expression analysis in muscle tissue of sheep (Jeanplong et al, 2015) revealed higher expression levels of MSTN than those of IGF1. However, our data showed higher IGF1 mRNA levels than those of MSTN.…”

Section: Discussionmentioning

confidence: 94%

Correlation between gene expression profiles in muscle and live weight in Dzhalginsky Merino sheep

Skripkin

Квочко

Куличенко

et al. 2016

Rev Colomb Cienc Pecu

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Undernutrition regulates the expression of a novel splice variant of myostatin and insulin-like growth factor 1 in ovine skeletal muscle

Cited by 11 publications

References 54 publications

Healthy community‐living older men differ from women in associations between myostatin levels and skeletal muscle mass

Healthy community‐living older men differ from women in associations between myostatin levels and skeletal muscle mass

Genes expression profiles in the loin muscle of Manych Merino sheep with different live weight

Correlation between gene expression profiles in muscle and live weight in Dzhalginsky Merino sheep

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