Climate variability is one of the leading natural threats and a root cause of food insecurity in the developing world, more so in Africa. It is a major impediment to the accomplishment of the global Sustainable Development Goals (SDGs), Vision 2030 and Big Four agenda in the Kenyan context. The rise in occurrence and brutality of extreme events resulting from variability of climate including prolonged flooding and drought has become more pronounced in the relatively drier areas. This chapter presents a synthesis about rural communities in Garissa and Tana River Counties, Kenya. The key environmental conditions that face the rural communities in the two counties are prolonged drought and recurrent flooding events. The two conditions have resulted in various challenges facing the communities in these regions through low agricultural production (food and pastures), poor infrastructure, human displacement, and the resultant extreme poverty, overall food insecurity, and tough livelihoods. The problems have been exacerbated by lack of capacity by most of the community members to cushion themselves against these impacts. However, as the conditions continue to manifest themselves, the community members have also identified adaptive mechanisms that are best suited in the region including planting drought-resistant crop varieties, diversifying their livelihoods, embrace sustainable land use, and made efforts to plant trees. We, therefore, conclude that integrated information sharing including early warning alongside affordable and appropriate technologies and crop insurance could be an entry point in cushioning the local communities in the arid and semiarid lands (ASALs) against the extreme weather conditions experienced in the region.