Anthropogenic ambient fine particulate matter less than 2.5 μm (PM 2.5 ) air pollution from fossil fuel combustion (eg, coal-fired power plants and traffic) ranks among the leading causes of worldwide morbidity and mortality. 1 In agreement with figures from the World Health Organization (http://www.who.int/topics/global _burden_of_disease/en/), estimations indicate that approximately 3.15 million deaths per year are attributable to PM 2.5 . This alarming figure exceeds that of many more widely recognized risk factors (eg, hypercholesterolemia) and unfortunately is estimated to double by 2050. 1 However, perhaps underappreciated by health care professionals and the general populace alike is that the largest portion of ambient PM 2.5 -induced health effects are owing to cardiovascular events. Short-term elevations in PM 2.5 increase the risk for myocardial infarctions, strokes, heart failure, arrhythmias, and cardiac death. 2,3 Longer-term exposures synergistically increase this acute risk and can even potentiate the development of chronic cardiometabolic conditions including diabetes and hypertension. As such, both the American Heart Association and European Society of Cardiology have formally recognized ambient PM 2.5 as a major cardiovascular risk factor. 2,3 While nearly all of humanity is adversely affected, the public health burden of ambient PM 2.5 is disproportionately felt by rapidly developing countries. 1,4 More than 99% of individuals living in east and south Asia are chronically exposed to PM 2.5 levels exceeding annual World Health Organization Air Quality Guidelines (<10 μg/m 3 ) compared with less than 20% in North America. 4 On top of this prevailing poor air quality, daily concentrations routinely exceed 100 μg/m 3 (5-to 10-fold greater than those across the United States) in megacities such as New Delhi, India, and Beijing, China. Unfortunately, extreme air pollution episodes (greater than 750-1000 μg/m 3 ) lasting several weeks per year are becoming all too routine (eg, the Chinese "airpocalypse " ). While improvements in air quality in the United States during the past few decades, largely owing to governmental National Ambient Air Quality Standards, have translated into significant improvements in life expectancy, 5,6 the opposite trend continues throughout much of Asia. 4 Successful widespread pollutioncontrol measures and advancements in using "green" technologies face numerous (eg, economic, infrastructure, and political) near-term barriers. 7 A substantial reduction from annual PM 2.5 levels in India and China (mean of 59 μg/m 3 and 41 μg/m 3 , respectively) require a major paradigm shift in human activity, and at the present rate of development, solving the worsening soci-VIEWPOINT