Understanding and Application of Daptomycin-Susceptible Dose-Dependent Category for <i>Enterococcus</i>: A Mixed-Methods Study

Adema, Jennifer L; Lake, Laurel N; Stevens, Ryan W; Hogan, Breann M.; Schuetz, Audrey N.; Tande, Aaron J.; Mara, Kristin C.; Eberly, Allison R.; Rivera, Christina G.

doi:10.1093/ofid/ofab611

Cited by 2 publications

(3 citation statements)

References 5 publications

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“…such as the revised daptomycin breakpoints for enterococci. [53][54][55][56] This cooperation will continue to be essential moving forward to ensure the technological strides made in areas such as wholegenome sequencing and pharmacokinetic/pharmacodynamic (PK/ PD) modeling can keep pace with the increasing complexity and prevalence of AMR and new drug development. On a global level, increased awareness and appreciation for the importance of AST through better communication should improve collaboration between key stakeholders and help identify solutions needed to maximize the availability and use of AST platforms.…”

Section: Ta B L E 1 (Continued)mentioning

confidence: 99%

“…In addition to avoiding potential negative outcomes, strong collaboration between clinicians and the microbiology laboratory can help clinicians utilize AST results more effectively via a high‐yield, low‐cost antimicrobial stewardship intervention via cascade or selective reporting of AST results for example 51,52 . At the population level, increased synergy between clinicians and microbiologists through CLSI has helped produce more comprehensive breakpoint recommendations that have shifted clinical practice and positively impacted patient outcomes, such as the revised daptomycin breakpoints for enterococci 53–56 . This cooperation will continue to be essential moving forward to ensure the technological strides made in areas such as whole‐genome sequencing and pharmacokinetic/pharmacodynamic (PK/PD) modeling can keep pace with the increasing complexity and prevalence of AMR and new drug development.…”

Section: Implementing and Optimizing Astmentioning

confidence: 99%

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Antimicrobial susceptibility testing: An updated primer for clinicians in the era of antimicrobial resistance: Insights from the Society of Infectious Diseases Pharmacists

et al. 2023

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Antimicrobial susceptibility testing (AST) is a critical function of the clinical microbiology laboratory and is essential for optimizing care of patients with infectious diseases, monitoring antimicrobial resistance (AMR) trends, and informing public health initiatives. Several methods are available for performing AST including broth microdilution, agar dilution, and disk diffusion. Technological advances such as the development of commercial automated susceptibility testing platforms and the advent of rapid diagnostic tests have improved the rapidity, robustness, and clinical application of AST. Numerous accrediting and regulatory agencies are involved in the process of AST and setting and revising breakpoints, including the U.S. Food and Drug Administration and the Clinical and Laboratory Standards Institute. Challenges to optimizing AST include the emergence of new resistance mechanisms, the development of new antimicrobial agents, and generation of new data requiring updates and revisions to established methods and breakpoints. Together, the challenges in AST methods and their interpretation create important opportunities for well-informed clinicians to improve patient outcomes and provide value to antimicrobial stewardship programs, especially in the setting of rapidly changing and increasing AMR. Addressing AST challenges will involve continued development of new technologies along with collaboration between clinicians and the laboratory to facilitate optimal antimicrobial use, combat the increasing burden of AMR, and inform the development of novel antimicrobials. This updated primer serves to reinforce important principles of AST, and to provide guidance on their implementation and optimization.

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Section: Ta B L E 1 (Continued)mentioning

confidence: 99%

Section: Implementing and Optimizing Astmentioning

confidence: 99%

Antimicrobial susceptibility testing: An updated primer for clinicians in the era of antimicrobial resistance: Insights from the Society of Infectious Diseases Pharmacists

et al. 2023

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“…Potential Single-Dose Antibiotics for Infective Endocarditis Prophylaxis Based on Antimicrobial Coverage and Risk Mitigation in the Absence of High-Quality, Comparative Studies aEnterococcus spp, and in the case of prosthetic valve, coagulase-negative staphylococci44 ) and a β-lactam like ceftriaxone (if suspecting an odontogenic or gastrointestinal focus) or cefazolin (if suspecting methicillin-susceptible S aureus [MSSA]) may be reasonable, although alternative regimens are also possible and there is almost no direct comparative evidence (Box 1; eAppendix 3 in Supplement 1) [48][49][50]. Absent comparative outcomes studies, some authors prefer a daptomycin dose of 8 to 10 mg/kg if S aureus is suspected 51 and 10 to 12 mg/kg if enterococcus is being targeted 52. To minimize harm, the aminoglycosides and rifampin are best reserved for definitive therapy, if used at all.…”

mentioning

confidence: 99%

Guidelines for Diagnosis and Management of Infective Endocarditis in Adults

McDonald,

Aggrey,

Tarık Aslan

et al. 2023

JAMA Netw Open

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ImportancePractice guidelines often provide recommendations in which the strength of the recommendation is dissociated from the quality of the evidence.ObjectiveTo create a clinical guideline for the diagnosis and management of adult bacterial infective endocarditis (IE) that addresses the gap between the evidence and recommendation strength.Evidence ReviewThis consensus statement and systematic review applied an approach previously established by the WikiGuidelines Group to construct collaborative clinical guidelines. In April 2022 a call to new and existing members was released electronically (social media and email) for the next WikiGuidelines topic, and subsequently, topics and questions related to the diagnosis and management of adult bacterial IE were crowdsourced and prioritized by vote. For each topic, PubMed literature searches were conducted including all years and languages. Evidence was reported according to the WikiGuidelines charter: clear recommendations were established only when reproducible, prospective, controlled studies provided hypothesis-confirming evidence. In the absence of such data, clinical reviews were crafted discussing the risks and benefits of different approaches.FindingsA total of 51 members from 10 countries reviewed 587 articles and submitted information relevant to 4 sections: establishing the diagnosis of IE (9 questions); multidisciplinary IE teams (1 question); prophylaxis (2 questions); and treatment (5 questions). Of 17 unique questions, a clear recommendation could only be provided for 1 question: 3 randomized clinical trials have established that oral transitional therapy is at least as effective as intravenous (IV)–only therapy for the treatment of IE. Clinical reviews were generated for the remaining questions.Conclusions and RelevanceIn this consensus statement that applied the WikiGuideline method for clinical guideline development, oral transitional therapy was at least as effective as IV-only therapy for the treatment of IE. Several randomized clinical trials are underway to inform other areas of practice, and further research is needed.

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Understanding and Application of Daptomycin-Susceptible Dose-Dependent Category for Enterococcus: A Mixed-Methods Study

Cited by 2 publications

References 5 publications

Antimicrobial susceptibility testing: An updated primer for clinicians in the era of antimicrobial resistance: Insights from the Society of Infectious Diseases Pharmacists

Antimicrobial susceptibility testing: An updated primer for clinicians in the era of antimicrobial resistance: Insights from the Society of Infectious Diseases Pharmacists

Guidelines for Diagnosis and Management of Infective Endocarditis in Adults

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