Understanding and controlling the scarring response: The contribution of histology and microscopy

In Vivo Confocal Microscopy of Failing and Functioning Filtering Blebs

“…All blebs examined within the first 6 postoperative days were considered blebs in the early wound healing period [13][14][15] and therefore were classified as ''early'' blebs. All blebs examined after the sixth postoperative day were categorized as ''late'' blebs.…”

Comparison of Fornix- and Limbus-Based Conjunctival Flaps in Mitomycin C Trabeculectomy with Laser Suture Lysis in Japanese Glaucoma Patients

“…17 Eventually, aqueous leakage or oozing will occur from the bleb wall. [18][19][20][21][22] In some cases, these conditions are present before postoperative infection of trabeculectomy. [15][16][17][18] Paradoxically, if the bleb is weaker and thus more dangerous, surgical lowering of the IOP is more effective.…”

Phospholipases A2 in normal human conjunctiva and from patients with primary open-angle glaucoma and exfoliation glaucoma

“…Fibrosis or scar formation plays also an important role in filtration surgery outcome. Surgical failure is generally a result of excessive subconjunctival scarring at the site of surgery [36]. There is evidence that prolonged topical treatment of glaucoma induces conjunctival changes and it has an adverse effect on the outcome of filtration surgery [24,37].…”

“…In glaucoma surgery, anti-cancer agents such as 5-fluorouracil and mitomycin C have been applied to prevent scarring [21,36]. However, certain patient groups such as those who have topical glaucoma treatment, uveitis or previous eye surgery, fail filtration surgery even after 5-fluorouracil or mitomycin C treatment [36].…”

“…However, certain patient groups such as those who have topical glaucoma treatment, uveitis or previous eye surgery, fail filtration surgery even after 5-fluorouracil or mitomycin C treatment [36]. At present, the reason for this is unknown.…”