Understanding and management of male breast cancer: a critical review

Pant, K.; Dutta, Udayan

doi:10.1007/s12032-007-9034-y

Cited by 40 publications

(27 citation statements)

References 44 publications

(47 reference statements)

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“…A higher proportion for MBC of 7–14% has been observed in Sub-Saharan countries [32]. Studies from Nigeria depict a proportion of MBC ranging from 3.7% [33] to 8.9% [34] as compared to the US, where the proportion of male breast cancer is 1.12% [35]. Another disconcerting fact was that all the cases of male breast cancer in our study presented in LS, which was an observation similar to studies from Nigeria [33,34].…”

Section: Discussionmentioning

confidence: 99%

Clinical and Epidemiologic Profile of Breast Cancer in Tanzania

Burson

Soliman

Ngoma

et al. 2010

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Purpose Breast cancer is a highly heterogeneous disease globally. Public health prevention measures require an understanding of the burden of breast cancer and its risk factors. The purpose of this study was to describe the clinical, pathologic, and epidemiologic characteristics of breast cancer patients in Tanzania. Methods Data was abstracted from the medical records of all breast cancer patients attending Ocean Road Cancer Institute (ORCI) over a 2-year period from July 2007 to June 2009. Tumor tissue paraffin blocks were collected for all patients with available tissues for the determination of estrogen receptor (ER) and progesterone receptor (PR). Data for all patients was analyzed descriptively and by using unconditional logistic regression, by comparing early stage (ES), defined as stages I and II and late stage (LS), defined as stages III and IV patients to obtain odds ratios (ORs), 95% confidence intervals (CIs), and P -values. Results Among the 488 patients, stage was determined for 356 patients, 90.7% of whom presented in LS. Of the 57 tumor tissues, 49.1% were ER−/PR−. Patients with ulceration (OR = 4.97; 95% CI = 1.07, 23.04; p = 0.04) and peau d’orange (OR = 6.78; 95% CI = 1.48, 31.17; p = 0.01) were more likely to present in LS rather than ES. Male breast cancer accounted for 2.9% of all breast cancers and inflammatory breast cancer (IBC) comprised 4.3–5.5% of cases based on registered t4d diagnosis or the criteria of IBC signs, if t4d was not reported in the medical records. Conclusion Most breast cancer patients in Tanzania are diagnosed at advanced disease stages with about half of the tumors being ER−/PR−. These data strongly support that reducing barriers to care, down-staging of disease at diagnosis, implementation of clinical guidelines for management of advanced cases, and palliative care are the four most essential factors that need to be addressed to reduce morbidity and mortality from breast cancer in Tanzania. Further research is needed to quantify the magnitude and molecular features of two relatively rare forms of breast cancer that may account for a greater proportion of the burden of breast cancer in Tanzania compared to the USA and Western Europe: male breast cancer and IBC.

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Section: Discussionmentioning

confidence: 99%

Clinical and Epidemiologic Profile of Breast Cancer in Tanzania

Burson

Soliman

Ngoma

et al. 2010

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“…Data from Central Sudan show that to 2.3% (34/1505) of all breast cancer patients registered at NCI-UG between 1999 and 2010 are males [61], which is over two-fold higher than the proportion reported worldwide [62]. In this regard, the incidence of male breast cancer (MBC) is reportedly higher in sub-Saharan Africa [63].…”

Section: Male Breast Cancer In Sudanmentioning

confidence: 99%

Epidemiology, Pathology, Management and Open Challenges of Breast Cancer in Central Sudan: A Prototypical Limited Resource African Setting

Mariani–Costantini¹,

Elhassan²,

Aceto³

et al. 2017

Breast Cancer - From Biology to Medicine

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Litle is known about breast cancer in Sudan. According to the recent data published by the Khartoum Cancer Registry, breast cancer was the most common cancer among Sudanese women. Generally, breast cancer in native African women is characterized by young age at onset, occurrence in multiparous premenopausal patients, advanced stage at diagnosis, large tumor size, high-grade and triple-negative phenotype, with correspondingly poor prognosis. In Sudan, it was reported that about 70% of the women diagnosed with breast cancer were younger than 50 years old. We present here data from local and international publications as well as primary information from the National Cancer Institute in Wad Medani (one of the only two cancer hospitals of the country, both located in Central Sudan in Khartoum and Wad Medani). We provide an up-to-date situation analysis of breast cancer in Central Sudan as an example for an African reality and the various open challenges of breast cancer in a limited resource seting. A beter understanding of breast cancer in black African women is of global relevance, as there is an alarming increase in breast cancer among young black women worldwide, and these patients have the lowest survival rates.

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“…This strategy has been studied in females and it has demonstrated that it offers similar survival rates as in the corresponding therapy which was given in the adjuvant setting (Bergh et al,2001). Moreover, aromatase inhibitors and trastuzumab with Her-2/neu have also been subscribed in the preoperative setting in females in phase II randomized studies in combination with chemotherapy (Buzdar et al, 2005;Smith et al, 2005;Pant et al, 2008).…”

Section: Neoadjuvant Systemic Treatmentmentioning

confidence: 99%

Male Breast Carcinoma: Epidemiology, Risk Factors and Current Therapeutic Approaches

Zygogianni

Kyrgias²,

Gennatas³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Male breast cancer is a very rare disease with an incidence of about 0.5-1% comparing with the one of female breast cancer but relatively little is known about its cause. Treatment strategies for breast cancer in males are derived from studies performed among females. The probable reasons behind the frequent, late diagnoses presented at stages III or IV might be the lack of awareness. The rarity of the disease precludes large prospective randomized clinical trials. This study reviews male breast cancer and its risk factors, recommendations for diagnosis and the management of patients with male breast cancer.

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Understanding and management of male breast cancer: a critical review

Cited by 40 publications

References 44 publications

Clinical and Epidemiologic Profile of Breast Cancer in Tanzania

Clinical and Epidemiologic Profile of Breast Cancer in Tanzania

Epidemiology, Pathology, Management and Open Challenges of Breast Cancer in Central Sudan: A Prototypical Limited Resource African Setting

Male Breast Carcinoma: Epidemiology, Risk Factors and Current Therapeutic Approaches

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