Understanding and overcoming resistance to immunotherapy in genitourinary cancers

Evans, Sean T; Jani, Yash; Jansen, Caroline S; Yildirim, Ahmet; Kalemoglu, Ecem; Bilen, Mehmet Asim

doi:10.1080/15384047.2024.2342599

Cancer Biology & Therapy

2024

DOI: 10.1080/15384047.2024.2342599

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Understanding and overcoming resistance to immunotherapy in genitourinary cancers

Sean T Evans,

Yash Jani,

Caroline S Jansen

et al.

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Cited by 5 publications

References 125 publications

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Prognostic value of B7-H3 expression in metastatic renal cell carcinoma and its impact on immunotherapy response

Özalp,

Yörükoğlu,

Yıldırım

et al. 2024

BMC Cancer

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Stanniocalcin-1 in tumor immunity: acts via macrophages

Wang,

Qiang

et al. 2024

Front. Immunol.

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Tumor immune escape has become a research hotspot in the field of cancer immunotherapy. Tumor-associated macrophages (TAMs) are the key component of tumor microenvironment, which play a pivotal role in tumor immune escape by regulating the immunity checkpoints, inhibiting the activity of T lymphocytes and natural killer (NK) cells, and modulating proportion of different T cells. Stanniocalcin-1(STC1)is ubiquitously expressed in human body, which is proven to involve with tumor progression and clinical prognosis. Recently, STC1 is implicated in tumor microenvironment as a phagocytosis checkpoint, as well as regulates the immunity via macrophages. In the review, we discussed the role of STC1 and TAMs in tumor immunity and their crosstalk, hoping to provide references for the research of STC1 in tumor immunotherapy.

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Understanding and overcoming resistance to immunotherapy in genitourinary cancers

Cited by 5 publications

References 125 publications

Deep Learning Algorithm‑Based MRI Radiomics and Pathomics for Predicting Microsatellite Instability Status in Rectal Cancer: A Multicenter Study

Deep Learning Algorithm‑Based MRI Radiomics and Pathomics for Predicting Microsatellite Instability Status in Rectal Cancer: A Multicenter Study

Prognostic value of B7-H3 expression in metastatic renal cell carcinoma and its impact on immunotherapy response

Stanniocalcin-1 in tumor immunity: acts via macrophages

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